Cagrilintide

Nkọwa dị mkpirikpi:

Cagrilintide bụ ihe sịntetik, onye na-anabata amylin agonist nke na-eme ogologo oge mepụtara maka ọgwụgwọ oke ibu na nsogbu metabolic metụtara ibu. Site n'iṅomi hormone amylin, ọ na-enyere aka ịchịkwa agụụ, na-eme ka afọ ntachi dị ngwa ngwa, na ịkwalite satiety. A na-emepụta Cagrilintide API anyị dị ọcha site na njikọ kemịkalụ wee zute ụkpụrụ ọkwa ọgwụ, na-eme ka ọ dabara maka ojiji na usoro njikwa ibu dị elu.

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Cagrilintide API

Cagrilintidebụ ihe na-eme ogologo oge, na-emepụta kemịkalụamylin receptor agonist, mepụtara dị ka akwụkwọ akụkọ ọgwụgwọ makaoke ibu na nsogbu metabolic metụtara ibu. Emebere ya iji ṅomie mmetụta nkeamylin mmadụ, homonụ jikọtara ya na insulin site na mkpụrụ ndụ β-pancreatic, nke na-arụ ọrụ dị oke mkpa n'ịhazi oriri, mkpofu afọ, na satiety.

A na-emepụta cagrilintide dị ka aọgwụgwọ injectable otu ugboro kwa izu, na-enye ihe ngwọta na-ekwe nkwa nke ukwuu makanjikwa ibu na-adịghị ala ala, karịsịa mgbe a na-eji ya eme iheNchikota na GLP-1 agonists nnabatadị kaSemaglutide.

Usoro nke Omume

Cagrilintide na-arụ ọrụ ọgwụgwọ ya site na ijikọ na ịgbalitendị na-anabata amylin, na-eduga na:

Mbelata agụụ
Mwepu afọ na-egbu oge, nke na-agbatị mmetụta nke afọ ojuju
Mbelata oriri calorie na ụbara satiety

Usoro ọtụtụ usoro nke iri nri na-eme ka ọ bụrụ ezigbo nwa akwukwo maka ijikwaoke ibu na ihe egwu cardiometabolic metụtara ya.

Nyocha na Clinical Data

Cagrilintide egosila nsonaazụ na-ekwe nkwa n'ọtụtụ nnwale ụlọ ọgwụ, gụnyereUsoro nke abụọ nke Novo Nordisk mere:

Mgbe ejiri yanaanị ya, Cagrilintide na-eduga nadose dabere arọ ọnwụ, na ruoMbelata ịdị arọ ahụ 10.8%.ihe karịrị izu 26 na ndị buru ibu.
Mgbe olejikọtara ya na Semaglutide, mmetụta mbelata ibu na-abawanye nke ọma - imezu iheMbelata dị ukwuu na ịdị arọ ahụ karịa otu onye ọrụ naanị.
O gosilamma tolerabilitynaprofaịlụ nchekwa na-adịgide adịgide, na ọtụtụ ihe ọjọọ bụ ihe mgbaàmà nke eriri afọ.

Ụzọ nchikota a bụ akụkụ dị mkpa nkepipeline ọgwụ mgbochi oke ibu nke ọgbọ na-abịa, na-ezubere ọtụtụ ụzọ satiety (amylin + GLP-1).

Ogo na nrụpụta API

AnyịCagrilintide API:

A na-emepụta site na eluNgwakọta peptide siri ike (SPPS)na ịdị ọcha dị elu na nkwụsi ike kemịkalụ
Emebere ya makammepe usoro injectable
Zute mba ụwaụkpụrụ ọgwụ (ICH, GMP, FDA)
Dị napilot na-emepụta ihe n'ọtụtụ azụmahịa, adabara maka ụlọ ọgwụ na ụlọ ọrụ mmepụta ihe