CJC-1295

CJC-1295 API

CJC-1295bụ ihe sịntetik, tetrasisteded peptide analogue nkehormone na-ewepụta homonụ na-eto eto (GHH), emebere kana-akpali ma na-akwado mmepụta nke hormone uto endogenous (GH). N'adịghị ka nwa amaala GHRH, nke nwere obere ndụ ọkara, CJC-1295 gụnyereTeknụzụ Mgbakwunye Mgbakwunye ọgwụ (DAC)., na-ekwe ka ọ na-ejikọta covalently na albumin n'ime ọbara namee ka ọkara ndụ ndụ ya dị ogologo karịa ụbọchị 8. Ihe ọhụrụ a na-eme CJC-1295 aAnalog GHRH na-eme ogologo ogenwere ikike dị ukwuu namgbochi ịka nká, ụkọ uto, usoro metabolic, ọrịa na-emebi ahụ ike, na ọgwụ na-emegharị ahụ.

Usoro nke Omume

CJC-1295 na-arụ ọrụ naGHRH nnatadị na sel somatotropic na pituitary anterior. Ọrụ ndu ya na-eṅomi nke GHRH nke ala, mana ọ nwere ogologo ndụ ogologo ndụ n'ihi mgbanwe DAC. Omume a kwadoro na-enyere akantọhapụ pulsatile kwụsiri ike nke GHna ụba mmepụta nkeIhe na-eto eto dị ka insulin 1 (IGF-1).

Usoro ndị bụ isi gụnyere:

• Mkpali nke nzuzo GH endogenous

• Ogologo ogologo oge nke ọkwa IGF-1, na-akwado mmetụta anabolic

• Enweghị nkụda mmụọ dị mkpama ọ bụ downregulation na-aga n'ihu iji

• Mmezi lipolysis, njikọ protein, na mmụgharị cellular

Site n'ịkpalite ụzọ GH na IGF-1 nke anụ ahụ, CJC-1295 na-ezere ọtụtụ ihe ndọghachi azụ jikọtara ya na ọgwụgwọ GH exogenous, dị ka enweghị ike nnabata na nchegbu nchekwa.

Nchọpụta ọgwụgwọ na ike ahụike

1. Ụkọ Hormone Uto (GHD)

N'ime ule ụlọ ọgwụ nke mbụ, CJC-1295 egosila:

• Mmụba na-adịgide adịgide naGHnaIGF-1ọkwa ruo6-10 ụbọchịmgbe otu ntụtụ

• E belataraugboro igba ogwutụnyere GHRH analogues ma ọ bụ GH injections kwa ụbọchị

• Emelitere nnabata onye ọrịa yana nkwụsi ike nke homonụ

2. Ngwakọta ahụ na ichekwa akwara

Ọmụmụ anụmanụ na ụmụ mmadụ egosila na CJC-1295:

• Na-akwaliteuru muscle daberenana-ebelata abụba anụ ahụ, karịsịa abụba visceral

• Na-akwalitenjigide nitrogen na njikọ proteinna skeletal muscle

• Nwere ike inye aka na mgbake site nasarcopeniana ọnọdụ imefusị ahụ ike

3. Ngwa mgbochi ịka nká na ahụike

Dika ọkwa GH na IGF-1 na-agbadata na afọ, a na-amụwanye CJC-1295 dị kamgbochi ịka nká akaka:

• Meliteụra àgwànausoro mgbawa nke circadian

• kwaliteelasticity akpụkpọ, ọkpụkpụ njupụta, naọrụ mgbochi ọrịa

• Nkwadoike metabolismnaike ọgwụgwụ na-eguzogide

4. Iwu Metabolic

CJC-1295 na-egosi nkwa na ikwu okwuinsulin iguzogideMetabolism syndrome na-agụnye:

• Na-emeziwanyeeji glucose eme ihe

• Na-akwalitelipid oxidationnametabolism nke anụ ahụ adipose

• Na-akwadonjikwa ibun'ime ndị buru ibu ma ọ bụ tupu ọrịa shuga

API nrụpụta na njikwa ogo

At Ndị otu Gentolex, anyịCJC-1295 APIeji emeputaNgwakọta peptide siri ike (SPPS)ma mee ka ọ dị ọcha site na iji HPLC iji nweta ịdị ọcha dị elu na nkwekọ-na-batch.

Nkọwapụta igodo:

• Ịdị ọcha ≥ 99%(HPLC kwadoro)

• Ihe mgbaze dị ala na ọla dị arọ

• Endotoxin na-enweghị, ụzọ njikọ njikọ na-abụghị nke immunogen

• Dị naomenala quantity: milligram ka kilogram ọnụ ọgụgụ

Ngwa na Ọdịnihu Inwere ike

A na-ahụta CJC-1295 dị ka otu n'ime analogues GHRH na-ekwe nkwa ogologo oge, yana ngwa nwere ike na:

• Usoro ọgwụgwọ ụkọ GH ndị okenye

• Nlekọta ihe mejupụtara ahụ na oke ibu na ịka nká

• Ndozigharị site na mfu ahụ ma ọ bụ trauma

• Nkwalite arụmọrụ na mgbake na ntọala ụlọ ọgwụ ma ọ bụ egwuregwu

• Nkwado ọgwụgwọ na ike ọgwụgwụ na-adịghị ala ala, fibromyalgia, na neuroendocrine adịghị mma

Ọnwụnwa ụlọ ọgwụ na-aga n'ihu na-enyocha iji ya dị ka ihe ọzọGH recombinant, karịsịa na ndị mmadụ na-achọmma, ọzọ physiological mgbanwe homonụ.