Desmopressin acetate na-agwọ ọrịa shuga nke etiti Insipidus
Nkọwa ngwaahịa
| Aha | Desmopressin |
| Nọmba CAS | 16679-58-6 |
| Usoro ihe omimi | C46H64N14O12S2 |
| Ibu arọ molekụla | 1069.22 |
| Nọmba EINECS | 240-726-7 |
| Ntughari pụrụ iche | D25 +85.5 ± 2° (gbakọrọ maka peptide efu) |
| Njupụta | 1.56±0.1 g/cm3 (buru amụma) |
| RTECS Mba. | YW9000000 |
| Ọnọdụ nchekwa | Na-echekwa na 0°C |
| Solubility | H2O: soluble20mg/ml, doro anya, enweghị agba |
| Ọnụọgụ acidity | (pKa) 9.90±0.15 (buru amụma) |
Ụdị okwu
MPR-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-NH2; MINIRIN; [DEAMINO1, DARG8] VASOPRESSIN; [DEAMINO-CYS1, D-ARG8] -VASOPRESSIN; DDAVP, MMADỤ; DESMOPRESSIN; DESMOPRESSIN, MMADỤ; DESAMINO-[D-ARG8] VASOPRESSIN
Ngosipụta
(1) Ọgwụgwọ nke insipidus ọrịa shuga etiti. Mgbe ọgwụ nwere ike ibelata mmamịrị excretion, belata mmamịrị ugboro ma belata nocturia.
(2) Ọgwụgwọ nke enuresis nocturnal (ndị ọrịa dị afọ 5 ma ọ bụ karịa).
(3) Nyochaa ọrụ itinye uche na mmamịrị gbasara akụrụ, wee mee nchọpụta dị iche iche nke ọrụ gbasara akụrụ.
(4) Maka hemophilia na ọrịa ọgbụgba ọbara ndị ọzọ, ngwaahịa a nwere ike belata oge ọbara ọgbụgba ma gbochie ọbara ọgbụgba. Ọ nwere ike ibelata ọnụọgụ ọbara intraoperative na nke na-apụta mgbe ịwachara ahụ; karịsịa na njikọ ọbara mgbali elu nke a na-achịkwa nke ọma n'oge ịwa ahụ, ọ nwere ike ibelata ọbara ọgbụgba n'ime ime site na usoro dị iche iche, ma belata mmiri mmiri na-apụta mgbe ịwachara ahụ, nke nwere ike ịrụ ọrụ ka mma n'ichebe ọbara.
Ọgwụgwọ nke ọrịa shuga insipidus
Ọrịa shuga insipidus bụ n'ụzọ bụ isi nsogbu nke metabolism mmiri nke a na-egosipụta oke mmamịrị, polydipsia, hypoosmolarity, na hypernatremia. Enweghi oke ma ọ bụ zuru ezu nke vasopressin (insipidus ọrịa shuga etiti), ma ọ bụ ụkọ akụrụngwa nke vasopressin (nephrogenic diabetes insipidus) nwere ike ịmalite. N'ụlọ ọgwụ, ọrịa shuga insipidus yiri polydipsia nke mbụ, ọnọdụ nke ịṅụbiga mmanya ókè na-akpata site na arụrụ ọrụ nke usoro nhazi ma ọ bụ akpịrị ịkpọ nkụ. N'adịghị ka polydipsia nke mbụ, mmụba nke oriri mmiri na ndị ọrịa nwere ọrịa shuga insipidus bụ nzaghachi kwekọrọ na mgbanwe nke nrụgide osmotic ma ọ bụ oke ọbara.
