Etelcalcetide Hydrochloride

Etelcalcetide Hydrochloride API
Etelcalcetide Hydrochloride bụ akwụkwọ akụkọ sịntetik peptide calcimimetic emepụtara maka ọgwụgwọ hyperparathyroidism nke abụọ (SHPT) na ndị ọrịa nwere ọrịa akụrụ na-adịghị ala ala (CKD) na-anata hemodialysis. SHPT bụ ihe mgbagwoju anya na nke siri ike na ndị ọrịa CKD, nke e ji ọkwa parathyroid hormone (PTH) dị elu, na-akpaghasị calcium-phosphate metabolism, na ihe ize ndụ nke ọkpụkpụ na ọrịa obi.

Etelcalcetide na-anọchite anya calcimimetic ọgbọ nke abụọ, nke a na-enye ya n'ime intravenous, ma na-enye uru karịa ọgwụgwọ ọnụ nke mbụ dị ka cinacalcet site na imeziwanye nnabata yana ibelata mmetụta nke eriri afọ.

Usoro nke Omume
Etelcalcetide na-arụ ọrụ site na ijikọ na ịgbalite onye na-anabata calcium-sensing (CaSR) nke dị na sel parathyroid gland. Nke a na-eṅomi mmetụta physiological nke calcium extracellular, na-eduga:

Mgbochi nzuzo nke PTH

Mbelata ọkwa nke calcium na phosphate serum

Mmanya ịnweta nguzozi na ọkpụkpụ metabolism

Dị ka onye na-arụ ọrụ allosteric peptide nke CaSR, Etelcalcetide na-egosi nkọwapụta dị elu yana ọrụ na-adịgide adịgide na-esochi nchịkwa nchịkwa nke eriri afọ mgbe dialysis gasịrị.

Nnyocha ụlọ ọgwụ na mmetụta ọgwụgwọ
Etelcalcetide enyochala nke ukwuu na nnwale ụlọ ọgwụ nke 3, gụnyere EVOLVE, AMPLIFY, na ọmụmụ EQUIP. Isi ihe nchoputa gụnyere:

Mbelata dị ịrịba ama ma na-adịgide adịgide na ọkwa PTH na ndị ọrịa CKD na hemodialysis

Nchikota nke ọma nke calcium na phosphorus nke serum, na-enye aka na-eme ka ọkpụkpụ-mineral homeostasis dịkwuo mma

Nkwekọrịta ka mma ma e jiri ya tụnyere calcimimetics nke ọnụ (obere ọgbụgbọ na vomiting)

Emelitere nrubeisi nke onye ọrịa n'ihi nchịkwa IV ugboro atọ kwa izu n'oge oge dialysis

Uru ndị a na-eme Etelcalcetide ka ọ bụrụ nhọrọ ọgwụgwọ dị mkpa maka ndị na-ahụ maka nephrologists na-ejikwa SHPT na ọnụ ọgụgụ ndị ọrịa dialysis.

Ogo na Nrụpụta
API Etelcalcetide Hydrochloride anyị:

A na-ejikọta ya site na njikọ peptide siri ike (SPPS) na ịdị ọcha dị elu

Dabara na nkọwa ọkwa ọkwa ọgwụ, dabara adaba maka usoro injectable

Na-egosi ọkwa dị ala nke ihe mgbaze, adịghị ọcha na endotoxins

Enwere ike ịgbatị maka mmepụta nnukwu batch na-akwado GMP