Fitusiran

Fitusiran (API)

Ngwa nyocha:
Fitusiran API bụ RNA (siRNA) nke na-etinye aka na-arụ ọrụ nke a nyochara nke ọma na ngalaba hemophilia na ọrịa coagulation. Ọ lekwasịrị anyaantithrombin (AT ma ọ bụ SERPINC1)mkpụrụ ndụ ihe nketa na imeju iji belata mmepụta antithrombin. Ndị na-eme nchọpụta na-eji Fitusiran nyochaa usoro nnyonye anya RNA (RNAi), ịgbachi nkịtị n'ime imeju, yana usoro ọgwụgwọ ọhụụ maka ịhazigharị coagulation na ndị ọrịa hemophilia A na B, yana ma ọ bụ na-enweghị ihe mgbochi.

Ọrụ:
Fitusiran na-arụ ọrụ site n'imechi okwu nke antithrombin, ihe na-egbochi arịa ọbara ọbara, si otú a na-abawanye ọgbọ thrombin ma na-akwalite mmepụta nke clot. Usoro a na-enye usoro ọgwụgwọ prophylactic iji belata ọbara ọgbụgba na ndị ọrịa hemophilia. Dị ka API, Fitusiran na-eje ozi dị ka ihe na-arụsi ọrụ ike na usoro ọgwụgwọ subcutaneous na-eme ogologo oge iji mee ka ndụ dịkwuo mma na ibelata ibu ọgwụgwọ na nsogbu ọbara ọgbụgba.