Ipamorelin

Ipamorelin API

Ipamorelin bụ hormone na-emepụta pentapeptide synthetic na-ewepụta peptide (GHRP) nke nwere amino acid ise (Aib-His-D-2-Nal-D-Phe-Lys-NH₂). Ọ bụ GHSR-1a agonist na-ahọrọ nke nwere ikike ịkwalite mmepụta homonụ nke uto (GH) na nkọwa dị elu. E jiri ya tụnyere GHRP mbụ (dị ka GHRP-2 na GHRP-6), Ipamorelin na-egosi nhọrọ dị mma, nchekwa na nkwụsi ike nke ọgwụ na-enweghị mmetụta dị ukwuu na ọkwa nke hormones ndị ọzọ dị ka cortisol, prolactin ma ọ bụ ACTH.

Dị ka peptide API nke a na-akwanyere ùgwù nke ukwuu, a na-eji Ipamorelin eme ihe ugbu a na nchọpụta mgbochi ịka nká, nhazigharị egwuregwu, ntinye aka osteoporosis, mgbake postoperative na nhazi ọrụ metabolic.

Nnyocha na usoro nke ime ihe

Ipamorelin na-akwalite mwepụta nke hormone uto endogenous (GH) site na pituitary anterior site na-ahọrọ nke na-eme ka hormone secretion receptor (GHSR-1a) na-eto eto ma na-eṅomi omume ghrelin. Isi usoro ọgwụ ya gụnyere:
1. Na-akpali nzuzo GH
Ipamorelin na-ahọrọ GHSR-1a nke ukwuu, na-akpali pituitary gland ịhapụ GH na-enweghị mmetụta dị ukwuu na ACTH ma ọ bụ cortisol ọkwa, ma nwee nchebe endocrine ka mma.
2. Kwalite njikọ protein na mmezi cell
Site n'ịbawanye ọkwa IGF-1, ọ na-akwalite anabolism cell muscle, na-eme ka nrụzi anụ ahụ na ịmaliteghachi, ọ dịkwa mma maka nrụzi trauma, mgbake ịwa ahụ na ọgwụgwọ atrophy muscle.
3. Mma metabolism na abụba nkesa
GH nwere mmetụta nke mkpokọta abụba yana mmụba insulin. Ipamorelin nwere ike inye aka n'ịhazi ọnọdụ metabolic ma jiri ya mee nchọpụta banyere ọrịa metabolic na oke ibu.
4. Meziwanye njupụta ọkpụkpụ na mgbochi ịka nká
GH / IGF-1 axis nwere ike ịkwalite ọkpụkpụ ọkpụkpụ na ịnweta mineral. Ipamorelin na-egosi nkwa na mgbochi osteoporosis, mgbaji mgbaji na mgbochi ịka nká.
5. Mma circadian rhythm na ihi ụra mma
Ntọhapụ GH na-esonyekarị na ụra miri emi. Nnyocha achọpụtala na Ipamorelin nwere ike imeziwanye usoro ihi ụra ma melite ikike mgbake physiological.
Ọmụmụ ihe izizi na nkwenye nrụpụta ọrụ

Ọ bụ ezie na ọ ka nọ na preclinical / mmalite ụlọ ọgwụ, Ipamorelin egosila ezigbo nchekwa na ịdị irè na anụmanụ na ụfọdụ ọmụmụ mmadụ:

A na-abawanye ọkwa GH nke ukwuu (elu n'ime nkeji 30, na-adịgide ruo ọtụtụ awa)

Enweghị mmetụta pro-cortisol ma ọ bụ pro-ACTH doro anya, mmetụta endocrine na-achịkwa karịa

Melite oke akwara na ike (karịsịa n'ụdị anụmanụ ndị agadi)

Melite mgbake mgbe ịwachara ahụ yana ọsọ nrụzi anụ ahụ

Mmụba ọkwa IGF-1 na-enyere aka nrụzi cell na nzaghachi antioxidant

Tụkwasị na nke ahụ, Ipamorelin jikọtara ya na ndị ọzọ GHRH mimetics (dị ka CJC-1295) na ụfọdụ ọmụmụ gosipụtara mmetụta synergistic, na-eme ka ntọhapụ pulse nke GH dịkwuo elu.
Mmepụta API na mmesi obi ike

A na-akwado Ipamorelin API site na Gentolex Group anyị site na iji usoro nhazi usoro peptide siri ike (SPPS)***, a na-asachapụ nke ọma na nke ọma, dabara adaba maka nyocha sayensị na mmepe na iji pipeline mbụ nke ụlọ ọrụ ọgwụ.

Njirimara ngwaahịa gụnyere:

Ịdị ọcha ≥99% (nnwale HPLC)
Enweghị endotoxin, ihe mgbaze dị ala, mmetọ ion ọla dị ala
Nye akwụkwọ dị mma zuru oke: COA, akụkọ nyocha nkwụsi ike, nyocha ụdịdị adịghị ọcha, wdg.
Ọkwa gram~kilogram nwere ike ịhazi ya