Liragluti-arịa ọrịa shuga maka njikwa shuga ọbara nke ọbara ọ dịghị .204656-20-2
Nkọwa nke ngwaahịa
| Ikpe | 204656-20-2 | Molular | C172H265N43O51 |
| Molular ibu | 3751.20 | Mputa | Ucha |
| Ọnọdụ nchekwa | Lightzọ iguzogide ọkụ, 2-8 | Ngwugwu | Akpa aluil / vial |
| Nko | ≥98% | Mbubata | Ntinye oyi na nnyefe nchekwa |
Efrata na liraglutide
Ngwakọta Ọrụ:
Liraglutide (analog nke Gricagon na-adịkarị dị ka peptide-1 (glp-1) mepụtara site yist site na teknụzụ nke mkpụrụ ndụ mkpụrụ ndụ).
Aha kemịkal:
Ang34lys26- (N-ε- (n-αru (n-α-hexadecanoyl)) - Glp-1 [7-37]
Ihe ndị ọzọ:
Sydrodium Hydrogen Phosphate dihydrate, proslene glycol, hydrochloric acid na / ma ọ bụ sodium hydroxide (dị ka ndị na-agbanwe son naanị), phenol, na mmiri maka ogwu.
Akwukwo icho oru
Pịnye ọrịa shuga nke Abụọ
Liraglutide na-eme ka njikwa nke glucose ọbara. Ọ na - ebelata hyperglycemia (maka awa 24 mgbe ọ na - eme ka insulilin dị elu, site na ịba ụba glucose, ma na - ebelata ihe nzuzo glucagon.
Ọ dị mma maka ndị ọrịa nke shuga ọbara ya ka na-achịkwa nke na-adịghị mma mgbe ọ ga-anabata ọnọdụ kachasị mma ma ọ bụ sulfonylas naanị. A na-eji ya na njikọta na metforn ma ọ bụ sulfonylureas.
Ọ na-eme ihe na-adọrọ adọrọ, nke pụtara na ọ ga-akpali mgbochi insulin naanị mgbe ọkwa glutose ọbara dị elu karịa ka ọ dị ugbu a, na-egbochi "Citching". N'ihi ya, ọ na-egosi ihe ize ndụ nke hypoglycemia.
O nwere ikike ime ka apaptosis na mkpali nke sel nke beta sel (hụrụ n'ọmụmụ ihe anụmanụ).
Ọ na-ebelata agụụ ma na-egbochi oke ibu, dị ka egosiri na nkuzi isi na isi ihe na-enwu enwu.
Arụma ihe ọmụma
Liraglutide bụ analog 1 na 97% na - aga 97% na - agagharị na glp-1, nke nwere ike kechie ma rụọ ọrụ glp-1. Ndị na-ahụ maka GLP-1 bụ ebumnuche nke GLP-1. N'adịghị ka prostocinetic na profaịlụ plactional nke liraglutude na mmadụ dị mma maka usoro iwu dosion nke kwa ụbọchị. Mgbe ịgwụ mebiri emebi, usoro nke ihe dịtere aka na-agụnye: Njikọ onwe onye na-agbada na-ada; na-ejikọ ọnụ; Nnukwu Eng enzyme kwụsie ike ma si otú a nwee ogologo oge.
Ọrụ nke Liragluut bụ onye mebere ya site na mmekọrịta ya na GLP-1, na-ebute mmụba na ụba cyclic monophosphate (ogige). Liraglutide na-akpali insulan secrion na ndọkpụ glucose - nke na-adabere, ebe ị na-ebelata ihe nzuzo glucagon - n'ụzọ dị iche iche.
Ya mere, mgbe glucose glucose ọbara na-ebili, a na-akpali m insulin na-akpali, ebe a na-egbochi ihe nzuzo Glucagon. N'ụzọ dị iche, liraglutide na-ebelata insulin na nzuzo n'oge hypoglycemia na-enweghị mmerụ ahụ na nzuzo na-eme ihe nzuzo. Usoro ọgwụgwọ ọrịa hyraglutide na-agụnye ntakịrị ogologo oge nke gastric oge na-efu. Liraglutide na - ebelata ogo ahụ na anụ ahụ uka site na ibelata agụụ na ike ike.
