MOTS-C

Nkọwa dị mkpirikpi:

A na-emepụta MOTS-C API n'okpuru ọnọdụ GMP siri ike na-eji teknụzụ peptide synthesis (SPPS) siri ike iji hụ na ịdịmma ya dị elu, ịdị ọcha dị elu na nkwụsi ike dị elu maka nyocha na ọgwụgwọ ọgwụgwọ.
Njirimara ngwaahịa:

Ịdị ọcha ≥ 99% (nke HPLC na LC-MS kwadoro),
Obere endotoxin na ihe mgbaze fọdụrụnụ,
Emepụtara dị ka usoro ICH Q7 na GMP si dị,
Nwere ike nweta nnukwu mmepụta, site na milligram-larịị R&D batches ruo gram-larịị na ọkwa azụmahịa ọkọnọ.

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MOTS-C API

MOTS-C(Mitochondrial Open Reading Frame nke 12S rRNA Type-c) bụ 16-amino acid.peptide sitere na mitochondria (MDP)mebere ya site na genome mitochondrial. N'adịghị ka peptides nwere koodu nuklia ọdịnala, MOTS-c sitere na mpaghara 12S rRNA nke DNA mitochondrial ma na-arụ ọrụ dị mkpa nana-achịkwa metabolism cellular, nzaghachi nrụgide, na mmetụta insulin.

Dị ka akwụkwọ akụkọ ọgwụgwọ peptide,MOTS-c APIenwetala mmasị dị ukwuu n'ọhịa nkeọrịa metabolic, ịka nká, physiology mmega ahụ, na ọgwụ mitochondrial. A na-enyocha peptide dị ugbu a na nyocha nke preclinical kpụ ọkụ n'ọnụ ma na-ewere ya dị ka onye na-ekwe nkwa maka yaọgwụgwọ peptide na-esote ọgbọezubere iche maka ahụike metabolic na ogologo ndụ.

Usoro nke Omume

MOTS-c na-arụ ọrụ ya site namitochondrial-nuclear cross-okwu-usoro nke mitochondria na-ekwurịta okwu na nucleus iji nọgide na-enwe homeostasis cellular. A na-atụgharị peptide site na mitochondria gaa na nucleus na nzaghachi nke nrụgide metabolic, ebe ọ na-eme dị kametabolic regulatorsite n'imetụta mkpụrụ ndụ ihe nketa.

Usoro ndu ndu isi gụnyere:

Ntinye nke AMPK (protein kinase na-arụ ọrụ AMP):MOTS-c na-akpali AMPK, ihe mmetụta ike etiti, na-akwalitennabata glucose, fatty acid oxidation, na mitochondrial biogenesis.
Mmụba nke mmetụta insulin:MOTS-c na-abawanye nnabata insulin na akwara na anụ ahụ adipose, na-akawanye mmaglucose homeostasis.
Mbelata nke nrụgide oxidative na mbufụt:Site n'ịgbanwe nguzozi redox cell na ụzọ mgbama mkpali.
Iwu nke ọrụ mitochondrial na biogenesis:Na-akwado ahụike mitochondrial, karịsịa n'okpuru nrụgide ma ọ bụ ọnọdụ ịka nká.

Nchọpụta ọgwụgwọ na mmetụta ndu

Ọmụmụ ihe ọmụmụ egosila ọtụtụ mmetụta physiological na ọgwụgwọ nke MOTS-c na vitro na ụdị anụmanụ:

1. Ọrịa Metabolic (oke ibu, ụdị ọrịa shuga 2, nguzogide insulin)

Na-eme ka nnabata glucose dịkwuo mma ma na-ebelata ọkwa glucose ọbara
Na-akwaliteinsulin uchena-enweghị mmụba insulin
Na-akwaliteoke ibu na abụba oxidationna oke oke ibu butere nri

2. Mgbochi ịka nká na Ogologo ndụ

Ọkwa MOTS-c na-agbada site na afọ, yana mgbakwunye na oke oke merela ka egosirimụbaa ikike anụ ahụ, kwalite ọrụ mitochondrial, naigbu oge metụtara ọdịda afọ.
Na-eme ka mmega ahụ dịkwuo mma naakwara ntachi obisite na mmụba nke oxidative metabolism.

3. Nchedo nrụgide Mitochondrial na Cellular

Na-akwaliteịlanarị cellular n'okpuru nrụgide metabolic ma ọ bụ oxidativeọnọdụ.
Na-abawanye nkwupụta nke mkpụrụ ndụ ihe nketa jikọtara yammezi cellular na autophagy.

4. Ọrịa obi na Neuroprotective nwere ike ime

Ọmụmụ izizi na-atụ aro MOTS-c nwere ike ichebesel endothelial vaskụlama belata akara mgbakasị obi.
Njirimara neuroprotective nwere ike site naụzọ mgbochi mkpali na antioxidativea na-enyocha ya.

API nrụpụta na Àgwà ọma

At Ndị otu Gentolex, anyịMOTS-c APIeji arụpụtara yaNgwakọta peptide siri ike (SPPS)n'okpuru ọnọdụ GMP siri ike, na-ahụ maka ịdị mma dị elu, ịdị ọcha na nkwụsi ike maka nyocha na iji ọgwụgwọ eme ihe.