Kedu ihe ị maara maka GLP-1?

1. Nkọwa nke GLP-1

Glucagon-dị ka Peptide-1 (GLP-1) bụ homonụ na-emepụta n'ime eriri afọ mgbe erichara nri. Ọ na-arụ ọrụ dị oke mkpa na metabolism glucose site na ịkpali mmepụta insulin, na-egbochi mwepụta glucagon, na-ebelata nsị nke afọ, na ịkwalite mmetụta nke afọ ojuju. Mmetụta ndị a jikọtara ọnụ na-enyere aka ịhazi ọkwa shuga dị n'ọbara ma na-enye aka na njikwa ibu. Ndị na-anabata GLP-1 sịntetik na-eṅomi usoro okike ndị a, na-eme ka ha baa uru na ọgwụgwọ ụdị ọrịa shuga 2 na oke ibu.

2. Nhazi site na Ọrụ

Dabere na ọrụ physiological ya, GLP-1 na analogs ya nwere ike kewaa n'ọtụtụ ọrụ:

• Nhazi glucose ọbara: na-eme ka mwepụta insulin dịkwuo elu na nzaghachi nke ọkwa glucose dị elu ma na-egbochi secretion glucagon.
• Njikwa agụụ: Ọ na-arụ ọrụ na etiti agụụ ụbụrụ iji belata oriri oriri na ịbawanye satiety.
• Usoro nchịkwa eriri afọ: na-ebelata ịwụfu afọ, na-agbatị usoro nri nri ma na-enyere aka ịchịkwa spikes glucose postprandial.
• Uru akwara obi: Ụfọdụ ndị na-anabata GLP-1 egosila na ha belata ohere nke nnukwu ihe omume obi na ndị ọrịa na-arịa ọrịa shuga.
• Njikwa ibu: Site n'ịkwụsị agụụ na ịkwalite mbelata kalori, analogues GLP-1 na-akwado nwayọ nwayọ na mbelata ịdị arọ.

3. Njirimara GLP-1
GLP-1 nwere obere ndụ ọkara okike - naanị nkeji ole na ole - n'ihi na enzyme DPP-4 (dipeptidyl peptidase-4) na-emebi ya ngwa ngwa. Iji merie nke a, ndị na-eme nchọpụta ọgwụ mepụtara agonists GLP-1 synthetic na-eme ogologo oge dị kaSemaglutide, Liraglutide, Tirzepatide, naRetatrutide.

Ngwakọta ndị a gbanwere na-agbatị ọrụ site na awa ruo ụbọchị ma ọ bụ ọbụna izu, na-enye ohere maka dose otu ugboro kwa ụbọchị ma ọ bụ otu ugboro kwa izu.
Njirimara ndị bụ isi gụnyere:

• Omume dabere na glucose: na-ebelata ohere nke hypoglycemia ma e jiri ya tụnyere ọgwụgwọ insulin ọdịnala.
• Usoro abụọ ma ọ bụ atọ (na ọgwụ ọhụrụ): Ụfọdụ ụdị dị elu na-elekwasị anya ndị nnabata ndị ọzọ dị ka GIP ma ọ bụ glucagon receptors, na-akwalite uru metabolic.
• Mmelite metabolic zuru oke: na-ebelata HbA1c, na-emezi profaịlụ lipid, ma na-akwado mbelata ibu.

GLP-1 na analogs ya agbanweela usoro ọgwụgwọ metabolic ọgbara ọhụrụ site n'ịkwado ma ọrịa shuga na oke ibu n'otu oge - na-enye ọ bụghị naanị njikwa shuga ọbara kamakwa ọ na-adịte aka maka akwara obi na ịdị arọ.

4.Ọgwụgwọ GLP-1

5. GLP-1 Agonists na-anabata ndị na-anabata ya
Ụdị nnyefe a na-ahụkarị, ndị a gụnyere Liraglutide, Semaglutide, na Tirzepatide. A na-enye ha n'okpuru akpụkpọ ahụ, kwa ụbọchị ma ọ bụ kwa izu, na-enye ọrụ nnabata na-aga n'ihu maka njikwa glucose kwụsiri ike na mbelata agụụ.

5. Oral GLP-1 Nnabata Agonists
Nhọrọ ọhụrụ, dị ka Oral Semaglutide, na-enye ndị ọrịa mma na-enweghị agịga. Ọ na-eji teknụzụ na-eme ka mmịpụta dị elu iji nọgide na-enwe bioavailability mgbe a na-ewere ya n'ọnụ, na-eme ka nnabata ọgwụgwọ dị mma.

6. Usoro ọgwụgwọ ngwakọta (GLP-1 + Ụzọ ndị ọzọ)
Usoro ọgwụgwọ na-apụta na-ejikọta GLP-1 na GIP ma ọ bụ glucagon receptor agonism iji nweta mfu arọ siri ike na nsonaazụ metabolic. Dịka ọmụmaatụ, Tirzepatide (GIP/GLP-1 agonist dual) na Retatrutide (GIP/GLP-1/glucagon agonist atọ) na-anọchi anya ọgbọ na-esote ọgwụgwọ metabolic.

Usoro ọgwụgwọ GLP-1 na-egosi mgbanwe mgbanwe n'ịchịkwa ọrịa metabolic na-adịghị ala ala - na-enye usoro agbakwunyere iji chịkwaa shuga ọbara, ibelata ibu, yana melite nsonaazụ ahụike n'ozuzu ya.