MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) bụ obere peptide nke DNA mitochondrial debere nke dọtara mmasị sayensị dị ukwuu n'afọ ndị na-adịbeghị anya. Na omenala, a na-ele mitochondria anya dị ka "ụlọ ike nke cell," na-ahụ maka mmepụta ike. Otú ọ dị, nchọpụta na-apụta na-ekpughe na mitochondria na-arụkwa ọrụ dị ka ebe ngosi, na-achịkwa metabolism na ahụike cellular site na peptides bioactive dị ka MOTS-c.
A na-etinye peptide a, nke nwere naanị amino acid 16, n'ime mpaghara 12S rRNA nke DNA mitochondrial. Ozugbo emebere ya na cytoplasm, ọ nwere ike ịtụgharị n'ime oghere, ebe ọ na-emetụta okwu nke mkpụrụ ndụ ihe nketa na-etinye aka na nhazi usoro metabolic. Otu n'ime ọrụ ya kachasị mkpa bụ ịgbalite ụzọ akara AMPK, nke na-eme ka nnabata glucose na iji ya na-eme ka ọ dịkwuo mma. Ngwongwo ndị a na-eme MOTS-c ka ọ bụrụ onye na-ekwe nkwa maka ịgwọ ọrịa metabolic dị ka ụdị ọrịa shuga 2 na oke ibu.
Na agafe metabolism, MOTS-c egosila mmetụta nchebe megide nrụgide oxidative site n'ịkwado nchebe antioxidant nke cell na ibelata mmebi nke free radicals kpatara. Ọrụ a na-enye aka n'ịkwado ahụike nke akụkụ ahụ dị oke egwu dịka obi, imeju, na usoro ụjọ. Nnyocha egosiwokwa njikọ doro anya n'etiti ọkwa MOTS-c na ịka nká: ka ahụ na-etolite, ọkwa okike nke peptide na-ebelata. Mgbakwunye na ọmụmụ anụmanụ emewo ka arụ ọrụ anụ ahụ dịkwuo mma, igbu oge n'ihi afọ, na ọbụna ogologo ndụ, na-ebuli ohere nke ịmepụta MOTS-c dị ka "molecule mgbochi ịka nká."
Tụkwasị na nke ahụ, MOTS-c na-egosi na ọ na-eme ka ume ike nke anụ ahụ na ntachi obi, na-eme ka ọ nwee mmasị dị ukwuu na nkà mmụta ọgwụ egwuregwu na nhazigharị. Ụfọdụ ọmụmụ na-egosikwa uru ndị nwere ike ime maka ọrịa neurodegenerative, na-agbasawanye mbara igwe ọgwụgwọ ya.
Ọ bụ ezie na ọ ka nọ na mmalite nke nyocha, MOTS-c na-anọchite anya mmetuta na nghọta anyị banyere bayoloji mitochondrial. Ọ bụghị naanị na ọ na-agbagha echiche ọdịnala nke mitochondria kamakwa ọ na-emepe ụzọ ọhụrụ maka ọgwụgwọ ọrịa metabolic, ibelata ịka nká, na ịkwalite ahụike n'ozuzu ya. N'ịga n'ihu na ọmụmụ ihe na mmepe ụlọ ọgwụ, MOTS-c nwere ike ịghọ ngwá ọrụ dị ike n'ọdịnihu nke ọgwụ.
Oge nzipu: Sep-10-2025