Retatrutide na-agbanwe agbanwe ka esi emeso oke ibu

N'ime ọha mmadụ taa, oke ibu aghọwo ihe ịma aka ahụike zuru ụwa ọnụ, na nputa nkeRetatrutidena-enye olileanya ọhụrụ maka ndị ọrịa na-alụso oke ibu ọgụ. Retatrutide bụ aatọ agonist receptorezubere icheGLP-1R, GIPR na GCGR. Usoro synergistic nke nwere ọtụtụ ebumnuche pụrụ iche na-egosipụta ikike pụrụiche maka ịbelata ibu.

Mechanistically, Retatrutide na-arụ ọrụNdị na-anabata GLP-1, nke na-akwalite mmepụta insulin, na-egbochi mwepụta glucagon, ma na-egbu oge ịwụsa afọ, si otú a na-eme ka satiety dịkwuo elu ma na-ebelata oriri. Ya ebighị nkeNdị na-anabata GIPna-eme ka mmetụta insulin dịkwuo mma, na-achịkwa metabolism lipid, ma na-arụkọ ọrụ ọnụ na GLP-1 iji kwalite mmetụta na-ebelata ibu. More mkpa, ya ebighị nkeNdị na-anabata glucagon (GCGR)na-abawanye mmefu ike, na-eme ka mgbochi gluconeogenesis imeju dịkwuo mma, ma na-ebelata mkpokọta abụba imeju - ọnụ, ụzọ ndị a na-enye aka na mfu dị arọ.

N'ime ule ụlọ ọgwụ, mmetụta mbelata ibu nke Retatrutide dị ịrịba ama. N'ime usoro ọmụmụ ụlọ ọgwụ nke izu 48, ndị sonyere na-anata dose 12 mg nke Retatrutide kwa izu tụfuru nkezi.24.2% nke ibu ahụ ha- nsonaazụ karịrị ọtụtụ ọgwụ na-ebelata ibu nke ọdịnala wee bịaruo ịdị irè nke ịwa ahụ bariatric. Ọzọkwa, oke ibu na-aga n'ihu na-akawanye mma ka oge na-aga; siteizu 72, nkezi arọ mbelata ruru ihe dị ka28%.

E wezụga mmetụta ya na-ebelata ibu dị ike, Retatrutide na-egosipụtakwa nnukwu nkwa na ịkwalite nsogbu ndị metụtara oke ibu. Ọ nwere ike belata ọbara mgbali elu, melite profaịlụ lipid, belata ọkwa triglyceride, ma na-enye nchebe obi - na-eweta.uru ahụike zuru okenye ndị mmadụ bi na oke ibu.