Okwu mmalite
Tirzepatide, nke Eli Lilly mepụtara, bụ ọgwụ peptide ọhụrụ nke na-anọchite anya ihe dị ịrịba ama na ọgwụgwọ ụdị ọrịa shuga 2 na oke ibu. N'adịghị ka omenala GLP-1 (glucagon-dị ka peptide-1) agonists, Tirzepatide na-eme ihe.ma GIP (glucose-based insulinotropic polypeptide)naNdị na-anabata GLP-1, na-enweta ya aha nke adual receptor agonist. Usoro abụọ a na-enyere aka ịrụ ọrụ nke ọma n'ịhazi glucose ọbara yana ibelata ibu ahụ, ọkachasị maka ndị ọrịa nwere ụdị ọrịa shuga 2 na oke ibu.
Usoro nke Omume
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GIP nnabata ọrụ: Na-eme ka mmepụta insulin dịkwuo elu ma na-eme ka nnabata glucose dịkwuo mma.
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GLP-1 nnabata nnabata: Na-akwalite mwepụta insulin, na-egbochi mmepụta nke glucagon, ma na-ebelata nsị nke afọ.
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Mmekọrịta abụọ: Na-enye njikwa glycemic dị irè na mbelata ibu dị ukwuu.
Nyocha data Clinical
1. Ọnwụnwa SURPASS (Ụdị Ọrịa shuga 2)
N'ofe otutuSURPASS nnwale ụlọ ọgwụ, Tirzepatide karịrị insulin na Semaglutide na nsonaazụ mbelata glycemic na ibu.
| Otu ndị ọrịa | Ọgwụ | Nkeji Mbelata HbA1c | Nkeji Mbelata ibu |
|---|---|---|---|
| Ụdị ọrịa shuga 2 | 5 mg | -2.0% | -7.0 n'arọ |
| Ụdị ọrịa shuga 2 | 10 mg | -2.2% | -9,5 n'arọ |
| Ụdị ọrịa shuga 2 | 15 mg | -2.4% | -11.0 n'arọ |
➡ Tụnyere Semaglutide (1 mg: HbA1c -1.9%, arọ -6.0 n'arọ), Tirzepatide gosipụtara nsonaazụ dị elu na njikwa glycemic na mbelata ibu.
2. Ọnwụnwa SURMOUNT (Obesity)
N'ime ndị ọrịa buru oke ibu na-enweghị ọrịa shuga, Tirzepatide gosipụtara ịdị irè dị oke ibu-mbelata.
| Ọgwụ | Nkeji Mbelata arọ (izu 72) |
|---|---|
| 5 mg | -15% |
| 10 mg | -20% |
| 15 mg | -22.5% |
➡ Maka onye ọrịa na-eru kilogram 100, Tirzepatide dị elu nwere ike nweta mbelata ịdị arọ nke gburugburu.22,5 n'arọ.
Uru ndị bụ isi
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Usoro abụọ: gafere otu GLP-1 agonists.
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Ịrụ ọrụ dị elu: Ọ dị irè ma njikwa glycemic na njikwa ibu.
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Ngwa ngwa ngwa: Kwesịrị ekwesị maka ma ọrịa shuga na oke ibu.
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Ike ahịa dị eluỌchịchọ maka ọgwụgwọ oke ibu Tirzepatide dị ka ọgwụ mgbochi n'ọdịnihu.
Outlook ahịa
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amụma nha ahịaN'afọ 2030, a na-atụ anya na ahịa ọgwụ GLP-1 zuru ụwa ọnụ ga-agafeUSD 150 ijeri, na Tirzepatide nwere ike weghara oke oke.
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Odida obodo asọmpi: Onye isi mgba bụ Novo Nordisk's Semaglutide (Ozempic, Wegovy).
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Uru: Data ụlọ ọgwụ na-egosi Tirzepatide na-enye oke ibu dị elu ma e jiri ya tụnyere Semaglutide, na-ewusi asọmpi ahịa ya na ọgwụgwọ oke ibu.
Oge nzipu: Sep-12-2025