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Kedu ihe bụ BPC-157

  • Aha n'uju:Ngwakọta nchekwa ahụ-157, aPentadecapeptide (15-amino acid peptide)mbụ dịpụrụ adịpụ na mmadụ gastric ihe ọṅụṅụ.

  • Amino acid usoro:Gly-Glu-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, molekụla arọ ≈ 1419.55 Da.

  • E jiri ya tụnyere ọtụtụ peptides ndị ọzọ, BPC-157 kwụsiri ike na mmiri na ihe ọṅụṅụ gastric, nke na-eme ka nchịkwa ọnụ ma ọ bụ gastric dịkwuo irè.

Usoro nke Omume

  1. Angiogenesis / mgbake okirikiri

    • Na-akwaliteVEGFR-2okwu, na-akwalite nhazi arịa ọbara ọhụrụ.

    • Na-arụ ọrụSrc-Caveolin-1-eNOS ụzọ, na-eduga na ntọhapụ nitric oxide (NO), vasodilation, na arụ ọrụ vaskụla ka mma.

  2. Anti-inflammatory & antioxidant

    • Na-agbadata cytokines pro-inflammatory dị kaIL-6naTNF-a.

    • Na-ebelata mmepụta ụdị ikuku oxygen (ROS), na-echebe mkpụrụ ndụ site na nrụgide oxidative.

  3. Mmezi anụ ahụ

    • Na-akwalite mgbake nhazi na arụ ọrụ na akwara, akwara, na ụdị mmerụ ahụ akwara.

    • Na-enye neuroprotection na usoro nhụjuanya nke etiti ụdị mmerụ ahụ (mkpakọ ọkpụkpụ azụ, ụbụrụ ischemia-reperfusion), na-ebelata ọnwụ neuronal na ịkwalite mgbake moto/sensory.

  4. Iwu nke ụda akwara

    • Ex vivo vaskụla ọmụmụ na-egosi BPC-157 na-ebute vasorelaxation, dabere na endothelium na-emebibeghị na ụzọ ọ bụla.

Data Comparative Animal & In Vitro

Ụdị nnwale Ụdị / Ntinye aka Usoro / nchịkwa Njikwa Nsonaazụ igodo Data atụnyere
Vasodilation (oke aorta, ex vivo) Mgbanaka aortic nwere nkwekọrịta phenylephrine BPC-157 ruo100 μg / ml Enweghị BPC-157 Vasorelaxation ~37.6 ± 5.7% E belatara ka10.0 ± 5.1% / 12.3 ± 2.3%na NOS inhibitor (L-NAME) ma ọ bụ NO scavenger (Hb)
Nyocha mkpụrụ ndụ endothelial (HUVEC) Omenala HUVEC 1 μg / ml Ejighị njikwa ↑ Ọ dịghị mmepụta (1.35 - okpukpu abụọ); Mbugharị cell Mbugharị ahụ kwụsịrị site na Hb
Ụdị akụkụ ụkwụ Ischemic (oke) Ọrịa ischemia 10 μg / kg / ụbọchị (ip) Enweghị ọgwụgwọ Mgbake ọbara ngwa ngwa, ↑ angiogenesis Ọgwụgwọ > Njikwa
Mpịakọta ọkpụkpụ azụ (oke) Sacrococcygeal mkpakọ ọkpụkpụ azụ Otu igba ogwu ip 10 min ka emeruchara ya Otu anaghị agwọ ọrịa Mmetụta akwara ozi na mgbake nhazi Ndị otu njikwa ahụ ka dara ada
Ụdị hepatotoxicity (CCl₄ / mmanya) mmerụ ahụ nke imeju kpatara kemịkalụ 1 μg ma ọ bụ 10 ng / kg (ip / ọnụ) Agwọghị ya ↓ AST/ALT, necrosis belatara Ndị otu nchịkwa gosipụtara mmerụ ahụ dị ukwuu nke imeju
Ọmụmụ ihe nsi Oke, oke bekee, nkịta Ọtụtụ doses / ụzọ Njikwa placebo Enweghị nsi dị mkpa, enweghị LD₅₀ hụrụ A nabatara nke ọma ọbụlagodi na oke doses

Ọmụmụ mmadụ

  • Usoro ikpe: Intra-articular injection of BPC-157 na 12 ọrịa na ikpere mgbu → 11 kọrọ mkpa mgbu mgbu. Oke: enweghị otu njikwa, enweghị kpuru ìsì, nsonaazụ nke onwe.

  • Nnwale ụlọ ọgwụ: A na-eduzi nchekwa nchekwa na usoro ọgwụ nke Mbụ (NCT02637284) na ndị ọrụ afọ ofufo 42 dị mma, mana ebipụtabeghị nsonaazụ ya.

Ugbu a,Enweghị nnwale ndị a na-achịkwa nke ọma (RCTs)dị iji kwado nrụpụta ụlọ ọgwụ na nchekwa.

Nchekwa & Ihe ize ndụ nwere ike ime

  • Angiogenesis: Ọ bara uru maka ọgwụgwọ, mana ọ nwere ike na-akwado usoro ọgwụgwọ tumor vaskụla, na-abawanye uto ma ọ bụ metastasis na ndị ọrịa cancer.

  • Usoro & nchịkwa: Ọ na-arụ ọrụ nke ọma na anụmanụ na obere doses (ng-µg/kg), mana usoro mmadụ na ụzọ kacha mma ka enweghị nkọwa.

  • Eji ogologo oge: Enweghị data toxicity zuru oke ogologo oge; ọtụtụ ọmụmụ na-adị mkpụmkpụ.

  • Ọkwa nchịkwa: A naghị akwado ya dị ka ọgwụ n'ọtụtụ mba; nkewa dị ka aihe amachibidoronke WADA (World Anti-Doping Agency).

Nghọta atụnyere & oke

Ntụnyere Ike Oke
Animal vs Human Mmetụta bara uru na-agbanwe agbanwe na anụmanụ (tendon, akwara, imeju imeju, angiogenesis) Ihe akaebe nke mmadụ dị ntakịrị, enweghị nchịkwa, na enweghị nleba anya ogologo oge
Oke dose Dị irè na obere doses na anụmanụ (ng-µg/kg; µg/ml in vitro) Amaghi usoro onunu ogwu mmadu nwere nchekwa/dị irè
Mmalite nke ime ihe Nlekọta mmalite nke mmerụ ahụ (dịka ọmụmaatụ, 10 min mgbe mmerụ ahụ gasịrị) na-enweta mgbake siri ike Amabeghị ihe gbasara ụlọ ọgwụ maka oge dị otú ahụ
Nsi Enweghị ọgwụ na-egbu egbu ma ọ bụ mmetụta ọjọọ dị egwu hụrụ n'ọtụtụ ụdị anụmanụ Nsi na-adịte aka, ọrịa carcinogenicity, na nchekwa ọmụmụ ka ka anwalebeghị

Mmechi

  • BPC-157 na-egosi mmetụta nrụpụta siri ike na nchebe na ụdị anụmanụ na sel: angiogenesis, mgbochi mbufụt, mmezi anụ ahụ, neuroprotection, na hepatoprotection.

  • Ihe akaebe mmadụ nwere oke oke, na-enweghị data nnwale ụlọ ọgwụ siri ike dị.

  • ỌzọkwaNnwale a na-achịkwa nke ọma nke ọmaachọrọ iji guzobe nrụpụta ọrụ, nchekwa, usoro ọgwụgwọ kachasị mma na ụzọ nchịkwa n'ime mmadụ.

Oge nzipu: Sep-23-2025
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