Retatrutide bụ agonist nke ọtụtụ ndị na-anabata ya, nke a na-ejikarị agwọ oke ibu na ọrịa metabolic. Ọ nwere ike rụọ ọrụ n'otu oge ndị na-anabata incretin atọ, gụnyere GLP-1 (glucagon-dị ka peptide-1), GIP (glucose-based insulinotropic polypeptide) na onye na-anabata glucagon. Usoro a dị iche iche na-eme ka retatrutide gosipụta ikike dị ukwuu na njikwa ibu, njikwa shuga ọbara na ahụike metabolic niile.
Isi atụmatụ na mmetụta nke retatrutide:
1. Ọtụtụ usoro nke ime ihe:
(1) GLP-1 agonism nnabata: Retatrutide na-akwalite secretion insulin ma na-egbochi ntọhapụ glucagon site na ịgbalite GLP-1 nnabata, si otú ahụ na-enyere aka belata shuga ọbara, na-egbu oge ịpụsị gastric na ibelata agụụ.
(2) Agbugbu ndị na-anabata GIP: Agbugbu ndị na-anabata GIP nwere ike ịkwalite mmepụta insulin ma nyere aka n'ihu belata shuga ọbara.
2. Glucagon receptor agonism: Glucagon receptor agonism nwere ike ịkwalite ire abụba na ike metabolism, si otú ahụ na-enyere aka ifelata.
3. Mmetụta ọnwụ dị oke mkpa: Retaglutide egosila mmetụta dị oke arọ na-efu na ọmụmụ ụlọ ọgwụ ma dị mma maka ndị ọrịa buru ibu ma ọ bụ ndị ọrịa nwere ọrịa metabolic syndrome. N'ihi ọtụtụ usoro eji eme ihe, ọ nwere arụmọrụ pụtara ìhè n'ibelata abụba anụ ahụ yana ịchịkwa ibu.
4. Njikwa shuga dị n'ọbara: Retaglutide nwere ike belata ọkwa shuga n'ọbara nke ọma ma dabara adaba maka ndị ọrịa nwere ụdị ọrịa shuga 2 chọrọ njikwa shuga ọbara. Ọ nwere ike inye aka mee ka mmetụta insulin dịkwuo elu ma belata mmụgharị shuga ọbara postprandial.
5. Ike ahụike obi obi: Ọ bụ ezie na retaglutide ka nọ na nyocha nyocha ụlọ ọgwụ, data mmalite na-egosi na ọ nwere ike ibelata ihe ize ndụ nke ihe omume obi, dịka nchebe obi nke ọgwụ GLP-1 ndị ọzọ.
6. nchịkwa nchịkwa: Retaglutide na-enye ugbu a site na ntụtụ subcutaneous, na-emekarị dị ka usoro ogologo oge otu ugboro n'izu, ugboro ugboro a na-enyere aka melite nnabata onye ọrịa.
7. Mmetụta: Mmetụta ndị a na-ahụkarị gụnyere mgbaàmà eriri afọ dị ka ọgbụgbọ, ọgbụgbọ na afọ ọsịsa, dịka mmetụta nke ọgwụ GLP-1 ndị ọzọ. Mgbaàmà ndị a na-adịkarị na mmalite ọgwụgwọ, ma ndị ọrịa na-ejikarị nwayọọ nwayọọ na-emegharị ka oge ọgwụgwọ na-abawanye.
Nnyocha ụlọ ọgwụ na ngwa:
Retaglutide ka na-aga ule ụlọ ọgwụ buru ibu, ọkachasị iji nyochaa nsonaazụ ya na nchekwa ogologo oge na ọgwụgwọ oke ibu. Nsonaazụ nnwale ụlọ ọgwụ na mbụ na-egosi na ọgwụ ahụ nwere mmetụta dị ukwuu na ọnwụ dị arọ na ahụike metabolic ka mma, ọkachasị maka ndị ọrịa nwere oke mmetụta nke ọgwụ ọdịnala.
A na-ahụta Retaglutide dị ka ụdị ọgwụ peptide ọhụrụ nwere ikike itinye n'ọrụ na ọgwụgwọ oke ibu, ọrịa metabolic na ụdị ọrịa shuga 2. Site na mbipụta nke data nnwale ụlọ ọgwụ n'ọdịnihu, a na-atụ anya na ọ ga-abụ ọgwụ ọzọ na-emepe emepe maka ọgwụgwọ oke ibu na ọrịa metabolic.
Oge nzipu: Mee-27-2025