Orlistat 96829-58-2 na-ebelata mmịkọ nke abụba Sietary, na-ebute mbelata ibu

Njirimara

White crystalline ntụ ntụ, ọ fọrọ nke nta ka ọ ghara ịsacha n'ime mmiri, na-agbaze ngwa ngwa na chloroform, soluble na methanol na ethanol, dị mfe pyrolyze, ebe mgbaze bụ 40℃ ~ 42℃. Ngwakọta ya bụ diastereomer nwere ụlọ ọrụ chiral anọ, na ogologo ogologo nke 529nm, ngwọta ethanol ya nwere ntụgharị anya na-adịghị mma.

Ụdị omume

Orlistat bụ onye na-eme ihe na-eme ogologo oge na nke nwere ike ime ihe mgbochi lipase eriri afọ, nke na-eme ka enzymes abụọ dị n'elu na-eme ka ọ bụrụ njikọ covalent na saịtị serine na-arụ ọrụ nke lipase na afọ na obere eriri afọ. Enzymes anaghị arụ ọrụ enweghị ike ịgbaji abụba dị n'ime nri n'ime acid fatty efu na akwụkwọ glycerol nke ahụ nwere ike ịmịnye ya, si otú ahụ belata oriri abụba na ibelata ibu. Na mgbakwunye, ụfọdụ ọmụmụ achọpụtala na orlistat na-egbochi nnabata eriri afọ nke cholesterol site na igbochi niemann-pick C1-like protein 1 (niemann-pickC1-like1, NPC1L1).

Ngosipụta

A na-egosi ngwaahịa a na nri hypocaloric dị nro maka ọgwụgwọ ogologo oge nke ndị buru oke ibu na ndị buru oke ibu, gụnyere ndị nwere ihe ize ndụ guzosiri ike metụtara oke ibu. Ngwaahịa a nwere njikwa ibu dị ogologo oge (mbelata ibu, mmezi arọ na mgbochi nke nlọghachi) nrụpụta ọrụ. Inweta orlistat nwere ike ibelata ihe ize ndụ metụtara oke ibu yana ọrịa ndị ọzọ metụtara oke ibu, gụnyere hypercholesterolemia, ụdị ọrịa shuga 2, nnabata glucose na-adịghị mma, hyperinsulinemia, ọbara mgbali elu, na mbelata abụba abụba.

Mmekọrịta ọgwụ

Nwere ike belata nnabata nke vitamin A, D na E. Enwere ike ịgbakwunye ngwaahịa a n'otu oge. Ọ bụrụ na ị na-ewere nkwadebe nwere vitamin A, D na E (dị ka ụfọdụ multivitamins), ị kwesịrị ị were ngwaahịa a awa 2 mgbe ị werechara ngwaahịa a ma ọ bụ n'oge ụra. Ndị nwere ụdị ọrịa shuga 2 nwere ike ịdị mkpa ibelata dose nke ọgwụ hypoglycemic ọnụ (dịka ọmụmaatụ, sulfonylureas). Ntinye aka na cyclosporine nwere ike ibute mbelata mkpokọta plasma nke ikpeazụ. Ojiji nke amiodarone n'otu oge nwere ike ibute mbelata nnabata nke ikpeazụ yana ibelata nrụpụta ọrụ.