Plozasiran

Nkọwa dị mkpirikpi:

Plozasiran API bụ obere RNA (siRNA) nke na-etinye aka na ya emebere maka ọgwụgwọ hypertriglyceridemia na ọrịa obi na ọrịa metabolic metụtara ya. Ọ lekwasịrị anyaAPOC3mkpụrụ ndụ ihe nketa, nke na-etinye koodu apolipoprotein C-III, bụ isi na-achịkwa metabolism triglyceride. N'ime nyocha, a na-eji Plozasiran mụọ usoro mgbada lipid dabere na RNAi, nkọwapụta mkpụrụ ndụ ihe nketa, yana ọgwụgwọ ogologo oge maka ọnọdụ dị ka ọrịa chylomicronemia nke ezinụlọ (FCS) na dyslipidemia agwakọta.

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Plozasiran (API)

Ngwa nyocha:
Plozasiran API bụ obere RNA (siRNA) nke na-etinye aka na ya emebere maka ọgwụgwọ hypertriglyceridemia na ọrịa obi na ọrịa metabolic metụtara ya. Ọ lekwasịrị anyaAPOC3mkpụrụ ndụ ihe nketa, nke na-etinye koodu apolipoprotein C-III, bụ isi na-achịkwa metabolism triglyceride. N'ime nyocha, a na-eji Plozasiran mụọ usoro mgbada lipid dabere na RNAi, nkọwapụta mkpụrụ ndụ ihe nketa, yana ọgwụgwọ ogologo oge maka ọnọdụ dị ka ọrịa chylomicronemia nke ezinụlọ (FCS) na dyslipidemia agwakọta.

Ọrụ:
Plozasiran na-arụ ọrụ site na ịgbachi nkịtịAPOC3mRNA na imeju, na-eduga na mbelata ọkwa C-III apolipoprotein. Nke a na-akwalite mmụba lipolysis na mkpochapụ nke lipoproteins bara ụba nke triglyceride site na ọbara. Dị ka API, Plozasiran na-enyere aka ịmepụta usoro ọgwụgwọ na-eme ogologo oge iji belata ọkwa triglyceride dị ukwuu na ibelata ihe ize ndụ nke ọrịa pancreatitis na ọrịa obi na ndị ọrịa nwere nnukwu ọrịa lipids ma ọ bụ mkpụrụ ndụ ihe nketa.

Nke gara aga: Givosiran

Osote: Zilebesiran

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