Ngwaahịa
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Peptides dị ọcha Retatrutide 10mg maka mbelata ibu na ọrịa shuga
Ịdị ọcha:>99%
Steeti: Lyophilized ntụ ntụ
Ọdịdị: White ntụ ntụ
Nkọwapụta: 5mg/10mg/15mg/20mg/30mg
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Retatrutide
Retaglutide bụ ọgwụ ọhụrụ dipeptidyl peptidase-4 (DPP-4) nke na-egbochi klaasị hypoglycemic nke nwere ike igbochi mmebi nke glucagon-dị ka peptide-1 (GLP-1) na glucose na-adabere na insulin na-ewepụta polypeptide (GIP) site na DPP-4 enzyme n'ime eriri afọ na ọbara, na-agbatịkwu insulin na-arụ ọrụ na-enweghị pancreatic. Basal larịị nke insulin na-ebu ọnụ, na-ebelata mpụta nke glucagon site na mkpụrụ ndụ α pancreatic, si otú a na-achịkwa shuga ọbara mgbe nri gasịrị. Ọ na-arụ ọrụ nke ọma na mmetụta hypoglycemic, nnabata na nnabata.
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Mbelata sodium
Inclisiran sodium API (Active Pharmaceutical Ingredient) ka a na-amụ nke ọma na nnyonye anya RNA (RNAi) na ọgwụgwọ ọrịa obi. Dị ka siRNA nwere eriri okpukpu abụọ na-ezubere iche maka mkpụrụ ndụ PCSK9, a na-eji ya na nyocha izizi yana nyocha ụlọ ọgwụ iji nyochaa usoro ịgbachi nkịtị na-eme ogologo oge maka iweda LDL-C (cholesterol lipoprotein dị ala). Ọ na-arụkwa ọrụ dị ka onyinye ihe atụ maka nyocha sistemu nnyefe siRNA, nkwụsi ike, yana ọgwụgwọ RNA lekwasịrị anya imeju.
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Fmoc-Gly-Gly-OH
Fmoc-Gly-Gly-OH bụ dipeptide a na-eji dị ka ihe mgbochi ụlọ n'ime peptide synthesis siri ike (SPPS). Ọ nwere ihe fọdụrụ glycine abụọ yana N-terminus na-echebe Fmoc, na-enye ohere maka elongation peptide chain nke na-achịkwa. N'ihi obere nha na mgbanwe nke glycine, a na-amụkarị dipeptide a n'ihe gbasara ọkpụkpụ azụ azụ peptide, nhazi njikọ, na nhazi nhazi na peptides na protein.
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Fmoc-Thr(tBu) -Phe-OH
Fmoc-Thr (tBu) -Phe-OH bụ ngọngọ ụlọ dipeptide nke a na-ejikarị na njikọ peptide siri ike (SPPS). Otu Fmoc (9-fluorenylmethyloxycarbonyl) na-echebe N-terminus, ebe otu tBu (tert-butyl) na-echebe ụdọ akụkụ hydroxyl nke threonine. A na-amụ dipeptide a echedoro maka ọrụ ya n'ịkwado elongation peptide nke ọma, na-ebelata ịgba ọsọ, na ịdepụta ebumnuche usoro kpọmkwem na nhazi protein na ọmụmụ mmekọrịta.
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AEEA-AEEA
AEEA-AEEA bụ hydrophilic, spacer na-agbanwe agbanwe nke a na-ejikarị na nyocha peptide na njikọ ọgwụ. Ọ mejupụtara nkeji abụọ ethylene glycol, na-eme ka ọ baa uru maka ịmụ ihe mmetụta nke ogologo njikọ na mgbanwe na mmekọrịta molecular, solubility, na ọrụ ndu. Ndị na-eme nchọpụta na-ejikarị nkeji AEEA nyochaa ka ndị na-ahụ maka oghere si emetụta arụmọrụ nke antibody-drug conjugates (ADCs), conjugates peptide-drug conjugates, na ndị ọzọ bioconjugates.
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![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide10-300x300.png)
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH
Ngwakọta a bụ ihe eji emepụta lysine na-echebe, arụ ọrụ nke ejiri mee ihe na njikọ peptide na mmepe conjugate ọgwụ. Ọ na-egosipụta otu Fmoc maka nchebe N-ọnụ, yana mgbanwe n'akụkụ ya na Eic (OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), na AEEA (aminoethoxyethoxyacetate). Emebere ihe ndị a iji mụọ mmetụta lipidation, kemistri spacer, na mwepụta ọgwụ a na-achịkwa. A na-enyocha ya nke ọma n'ihe gbasara atụmatụ prodrug, ADC linkers na peptides na-emekọrịta ihe.
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![Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide9-300x300.png)
Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH
Ngwakọta a bụ ihe lysine emezigharịrị eji eme ihe na njikọ peptide, ọkachasị maka imepụta conjugates peptide ezubere iche ma ọ bụ multifunctional. Otu Fmoc na-enye ohere maka njikọ nzọụkwụ site na Fmoc solid-phase peptide synthesis (SPPS). A na-eji ihe nrụpụta stearic acid (Ste), γ-glutamic acid (γ-Glu), na njikọ AEEA abụọ (aminoethoxyethoxyethoxyacetate), nke na-enye hydrophobicity, njikwa ụgwọ, na oghere mgbanwe. A na-amụkarị ya maka ọrụ ya na sistemụ nnyefe ọgwụ, gụnyere antibody-drug conjugates (ADCs) na peptides na-abanye cell.
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Liraglutide Anti-Diabetics maka njikwa shuga ọbara CAS NO.204656-20-2
Ihe na-arụ ọrụ:Liraglutide (analog nke mmadụ glucagon-dị ka peptide-1 (GLP-1) nke yist mepụtara site na teknụzụ recombination nke mkpụrụ ndụ ihe nketa.
Aha kemịkalụ:Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl))))-GLP-1[7-37]
Ngwa ndị ọzọ:Disodium Hydrogen Phosphate Dihydrate, Propylene Glycol, Hydrochloric Acid na/ma ọ bụ Sodium Hydroxide (dị ka pH Adjusters Only), Phenol, na Mmiri maka ịgba ọgwụ.
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Leuprorelin Acetate na-achịkwa secretion nke Hormones Gonadal
Aha: Leuprorelin
Nọmba CAS: 53714-56-0
Usoro ihe omimi: C59H84N16O12
Arọ molikula: 1209.4
Nọmba EINECS: 633-395-9
Ntụgharị pụrụ iche: D25 -31.7° (c = 1 n'ime 1% acetic acid)
Njupụta: 1.44± 0.1 g/cm3 (buru amụma)
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Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH
Boc-His(Trt)-Aib-Gln(Trt)-Gly-OHbụ tetrapeptide echedoro nke ejiri na njikọ peptide na ọmụmụ ihe nhazi. Otu Boc (tert-butyloxycarbonyl) na-echebe N-terminus, ebe ndị otu Trt (tryl) na-echebe ụdọ akụkụ nke histidine na glutamine iji gbochie mmeghachi omume na-achọghị. Ọnụnọ nke Aib (α-aminoisobutyric acid) na-akwalite nhazi nke helical ma na-eme ka nkwụsi ike peptide dịkwuo elu. Ihe peptide a bara uru maka nyocha mpịakọta peptide, nkwụsi ike, yana dịka ihe nhụcha maka imepụta peptides na-arụ ọrụ ndụ.
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BPC-157
BPC-157 API nakweere usoro nhazi usoro siri ike (SPPS):
Ịdị ọcha dị elu: ≥99% (nchọpụta HPLC)
Ihe fọdụrụ adịghị ọcha dị ala, enweghị endotoxin, enweghị mmetọ ọla dị arọ
Nkwụsi ike nke ogbe, nkwughachi siri ike, iji ọkwa injection nkwado
Nkwado gram na ọkwa ọkwa kilogram iji gboo mkpa nke ọkwa dị iche iche site na R&D ruo mmepụta ihe.