Ngwaahịa
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Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU bụ molekul njikọ lipidated synthetic emebere maka nnyefe ọgwụ ezubere iche yana mgbochi-ọgwụ conjugates (ADCs). Ọ nwere ọdụ stearoyl (Ste) hydrophobic, γ-glutamyl ezubere iche motif, AEEA spacers maka mgbanwe, yana otu OSu (NHS ester) maka njikọta nke ọma.
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Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH bụ ngọngọ ihe eji echekwa ihe eji eme ihe na-egosi α-methylated leucine, nke a na-ejikarị eme ihe n'ichepụta ọgwụ peptide iji kwalite nkwụsi ike nke metabolic na nhọrọ nnabata.
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Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) bụ ihe nchacha zwitterionic sịntetị nke a na-ejikarị na nyocha protein membrane na usoro ihe omimi, ọkachasị na NMR spectroscopy na crystallography.
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N-Acetylneuraminic Acid (Neu5Ac Sialic Acid)
N-Acetylneuraminic Acid (Neu5Ac), nke a na-akpọkarị sialic acid, bụ monosaccharide na-emekarị nke na-etinye aka na cellular dị egwu na ọrụ mgbochi. Ọ na-arụ ọrụ dị mkpa na nrịbama cell, nchebe pathogen, na mmepe ụbụrụ.
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Ergothionine
Ergothioneine bụ antioxidant sitere na amino acid sitere n'okike, nke a mụrụ maka cytoprotective dị ike na ihe mgbochi ịka nká. A na-emepụta ya site na fungi na nje bacteria na-agbakọba n'ime anụ ahụ ndị e kpughere na nrụgide oxidative.
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NMN
Ọmụmụ ihe ọmụmụ na mbụ na nke mmadụ na-atụ aro NMN nwere ike ịkwalite ogologo ndụ, ntachi obi anụ ahụ, na ịrụ ọrụ ọgụgụ isi.
Njirimara API:
Ịdị ọcha dị elu ≥99%
Pharmaceutical-ọkwa, adabara maka ọnụ ma ọ bụ injectable formulations
Emepụtara n'okpuru ụkpụrụ GMP
NMN API dị mma maka ojiji na mgbakwunye mgbochi ịka nká, usoro ọgwụgwọ metabolic, na nyocha ogologo ndụ.
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Glucagon
Glucagon bụ homonụ peptide sitere n'okike ejiri dị ka ọgwụgwọ mberede maka nnukwu hypoglycemia ma mụọ maka ọrụ ya na nhazi usoro metabolic, mbelata ibu, na nchọpụta mgbari nri.
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Motixafortide
Motixafortide bụ peptide synthetic CXCR4 antagonist emepụtara iji chịkọta mkpụrụ ndụ hematopoietic stem cell (HSCs) maka transplantation autologous na a na-amụkwa ya na oncology na immunotherapy.
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Glepaglutide
Glepaglutide bụ analog GLP-2 na-eme ogologo oge nke emepụtara maka ọgwụgwọ nke ọrịa bowel mkpụmkpụ (SBS). Ọ na-eme ka nnabata nke eriri afọ na uto, na-enyere ndị ọrịa aka belata ịdabere na nri parenteral.
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Elamipretide
Elamipretide bụ tetrapeptide ezubere iche nke mitochondria emepụtara iji gwọọ ọrịa sitere na arụrụ arụ mitochondrial kpatara, gụnyere isi mitochondrial myopathy, ọrịa Barth, na nkụda obi.
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Donidalorsen
Donidalorsen API bụ antisense oligonucleotide (ASO) na-enyocha nyocha maka ọgwụgwọ angioedema eketa (HAE) na ọnọdụ mkpali metụtara ya. A na-amụ ya na usoro ọgwụgwọ ezubere iche maka RNA, na-achọ ibelata okwu nkeplasma prekallikrein(KLKB1 mRNA). Ndị na-eme nchọpụta na-eji Donidalorsen chọpụta usoro ịgbachi nkịtị n'ime mkpụrụ ndụ ihe nketa, ọgwụ ọgwụ na-adabere na dose, na njikwa ogologo oge nke mbufụt mgbasa ozi bradykinin.
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Fitusiran
Fitusiran API bụ RNA (siRNA) nke na-etinye aka na-arụ ọrụ nke a nyochara nke ọma na ngalaba hemophilia na ọrịa coagulation. Ọ lekwasịrị anyaantithrombin (AT ma ọ bụ SERPINC1)mkpụrụ ndụ ihe nketa na imeju iji belata mmepụta antithrombin. Ndị na-eme nchọpụta na-eji Fitusiran nyochaa usoro nnyonye anya RNA (RNAi), ịgbachi nkịtị n'ime imeju, yana usoro ọgwụgwọ ọhụụ maka ịhazigharị coagulation na ndị ọrịa hemophilia A na B, yana ma ọ bụ na-enweghị ihe mgbochi.