Ngwaahịa
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Givosiran
Givosiran API bụ RNA (siRNA) nke na-etinye aka na ya nke a na-amụ maka ọgwụgwọ nke nnukwu imeju porphyria (AHP). Ọ kpọmkwem lekwasịrị anya naALAS1gene (aminolevulinic acid synthase 1), nke na-etinye aka na heme biosynthesis ụzọ. Ndị na-eme nchọpụta na-eji Givosiran nyochaa nnyonye anya RNA (RNAi), usoro ọgwụgwọ na-adabere na imeju, na imeju nke ụzọ metabolic na-etinye aka na porphyria na ọrịa mkpụrụ ndụ ihe nketa metụtara ya.
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Pegcetacoplan
Pegcetacoplan bụ peptide cyclic pegylated nke na-arụ ọrụ dị ka onye na-egbochi mmechi mmeju C3 ezubere iche, nke emepụtara maka ọgwụgwọ ọrịa ndị na-akwado nkwado dị ka paroxysmal nocturnal hemoglobinuria (PNH) na atrophy geographic (GA) na mmebi macular metụtara afọ.
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Plozasiran
Plozasiran API bụ obere RNA (siRNA) nke na-etinye aka na ya emebere maka ọgwụgwọ hypertriglyceridemia na ọrịa obi na ọrịa metabolic metụtara ya. Ọ lekwasịrị anyaAPOC3mkpụrụ ndụ ihe nketa, nke na-etinye koodu apolipoprotein C-III, bụ isi na-achịkwa metabolism triglyceride. N'ime nyocha, a na-eji Plozasiran mụọ usoro mgbada lipid dabere na RNAi, nkọwapụta mkpụrụ ndụ ihe nketa, yana ọgwụgwọ ogologo oge maka ọnọdụ dị ka ọrịa chylomicronemia nke ezinụlọ (FCS) na dyslipidemia agwakọta.
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Zilebesiran
Zilebesiran API bụ nyocha obere RNA (siRNA) na-etinye aka na nyocha nke emepụtara maka ọgwụgwọ ọbara mgbali elu. Ọ lekwasịrị anyaAGTmkpụrụ ndụ ihe nketa, nke na-etinye koodu angiotensinogen - akụkụ bụ isi nke sistemu renin-angiotensin-aldosterone (RAAS). Na nyocha, a na-eji Zilebesiran amụ usoro ịgbachi nkịtị maka mkpụrụ ndụ ọbara mgbali elu ogologo oge, teknụzụ nnyefe RNAi, yana ọrụ sara mbara nke ụzọ RAAS na ọrịa obi na akụrụ.
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Palopegteriparatide
Palopegteriparatide bụ parathyroid hormone receptor agonist (PTH1R agonist), nke emepụtara maka ọgwụgwọ hypoparathyroidism na-adịghị ala ala. Ọ bụ analọgụ pegylated nke PTH (1-34) emebere iji nye ụkpụrụ calcium na-adịgide adịgide site na iji usoro ọgwụgwọ otu ugboro kwa izu.
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GHRP-6
GHRP-6 (Homone uto na-ewepụta Peptide-6) bụ hexapeptide sịntetik nke na-arụ ọrụ dị ka secretagogue homonụ uto, na-akpali mwepụta anụ ahụ nke homonụ uto (GH) site na ịgbalite onye nnabata GHSR-1a.
Njirimara API:
Ịdị ọcha ≥99%
Emepụtara ya site na njikọ peptide siri ike (SPPS)
Enyere ya maka R&D na iji azụmaahịa
GHRP-6 bụ peptide nyocha dị iche iche maka nkwado metabolic, mmụgharị akwara, na mgbanwe homonụ.
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GHRP-2
GHRP-2 (Homone uto na-ewepụta Peptide-2) bụ hexapeptide sịntetị na ike nke uto homonụ secretagogue, emebere iji kpalite ntọhapụ eke nke hormone uto (GH) site na ịgbalite onye nnabata GHSR-1a na hypothalamus na pituitary.
Njirimara API:
Ịdị ọcha ≥99%
Dị maka R&D na nnyefe azụmahịa, yana akwụkwọ QC zuru ezu
GHRP-2 bụ peptide nyocha bara uru na ngalaba nke endocrinology, ọgwụ na-emegharị ahụ, na ọgwụgwọ metụtara afọ.
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Hexarelin
Hexarelin bụ peptide peptide na-eto eto na-eto eto sịntetik na GHSR-1a agonist dị ike, mepụtara iji kpalite ntọhapụ nke hormone uto endogenous (GH). Ọ bụ nke ezinụlọ ghrelin mimetic ma mejupụtara amino acid isii (hexapeptide), na-enye nkwụsi ike nke metabolic yana mmetụta mwepụta GH siri ike ma e jiri ya tụnyere analogs mbụ dị ka GHRP-6.
Njirimara API:
Ịdị ọcha ≥ 99%
Emepụtara site na njikọ peptide siri ike (SPPS)
Ụkpụrụ GMP dị ka, endotoxin dị ala na ihe fọdụrụ na ihe mgbaze
Ọbịbịa na-agbanwe agbanwe: R&D ruo nha azụmahịa
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Melanotan II
Njirimara API:
Ịdị ọcha dị elu ≥ 99%
Ejikọtara ya site na njikọ peptide siri ike (SPPS)
Endotoxin dị ala, ihe mgbaze dị ala
Dị na R&D n'ọtụtụ azụmahịa -
Melanotan 1
Emepụtara Melanotan 1 API site na iji teknụzụ siri ike peptide synthesis (SPPS) n'okpuru ọnọdụ njikwa mma dị ka GMP siri ike.
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Ịdị ọcha dị elu ≥99%
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Ngwakọta peptide siri ike (SPPS)
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Ụkpụrụ nrụpụta dị ka GMP
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Akwụkwọ zuru ezu: COA, MSDS, data kwụsie ike
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Nkwanye nwere ike ịgbakọ: R&D ruo ọkwa azụmahịa
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MOTS-C
A na-emepụta MOTS-C API n'okpuru ọnọdụ GMP siri ike na-eji teknụzụ peptide synthesis (SPPS) siri ike iji hụ na ịdịmma ya dị elu, ịdị ọcha dị elu na nkwụsi ike dị elu maka nyocha na ọgwụgwọ ọgwụgwọ.
Njirimara ngwaahịa:Ịdị ọcha ≥ 99% (nke HPLC na LC-MS kwadoro),
Obere endotoxin na ihe mgbaze fọdụrụnụ,
Emepụtara dị ka usoro ICH Q7 na GMP si dị,
Nwere ike nweta nnukwu mmepụta, site na milligram-larịị R&D batches ruo gram-larịị na ọkwa azụmahịa ọkọnọ. -
Ipamorelin
A na-akwado Ipamorelin API site na usoro usoro njikọ peptide siri ike (SPPS)** dị elu ma na-eme ka ọ dị ọcha na nnwale dị mma, dabara adaba maka iji pipeline mbụ na nyocha sayensị na mmepe na ụlọ ọrụ ọgwụ.
Njirimara ngwaahịa gụnyere:
Ịdị ọcha ≥99% (nnwale HPLC)
Enweghị endotoxin, ihe mgbaze dị ala, mmetọ ion ọla dị ala
Nye akwụkwọ dị mma zuru oke: COA, akụkọ nyocha nkwụsi ike, nyocha ụdịdị adịghị ọcha, wdg.
Ọkwa gram~kilogram nwere ike ịhazi ya