Semaglutide
Semaglutide API
Semaglutide bụ glucagon na-eme ogologo oge dị ka peptide-1 (GLP-1) agonist receptor, emepụtara maka ọgwụgwọ ụdị ọrịa shuga mellitus 2 na oke ibu. Emezigharịrị n'usoro iji guzogide mmebi enzymatic ma kwalite ọkara ndụ, Semaglutide na-enye ohere maka ịdị mma otu ugboro kwa izu, na-eme ka nnabata onye ọrịa dịkwuo mma.
AnyịSemaglutide APIA na-emepụta ya site na usoro sịntetik zuru oke, na-ewepụ ihe ize ndụ ndị metụtara usoro okwu ndu, dị ka protein cell host ma ọ bụ mmetọ DNA. Emepụtala ma kwado usoro nrụpụta niile n'ọ̀tụ̀tụ̀ kilogram, na-emezu ihe ndị siri ike chọrọ nke akọwapụtara na ntuziaka FDA nke 2021 na ntinye akwụkwọ ANDA maka ọgwụ peptide sịntetịt dị ọcha.
Usoro nke Omume
Semaglutide na-eṅomi mmadụ GLP-1, hormone incretin nke na-arụ ọrụ dị mkpa na metabolism glucose. Ọ na-eme site na ọtụtụ usoro synergistic:
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Na-akpali mmepụta insulinna usoro nke dabere na glucose
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Na-ebelata mmepụta nke glucagon, na-ebelata mmepụta glucose imeju
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Na-egbu oge mkpofu afọ, na-eduga n'ịkwalite njikwa glycemic postprandial
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Na-ebelata agụụ na ike oriri, na-akwado ọnwụ ọnwụ
Nsonaazụ ụlọ ọgwụ
Ọmụmụ ụlọ ọgwụ buru ibu (dịka ọmụmaatụ, ule SUSTAIN na STEP) egosila na Semaglutide:
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Na-agbadata nke ọma HbA1c na ọkwa glucose plasma na-ebu ọnụ na ndị ọrịa nwere ụdị ọrịa shuga 2
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Na-akwalite oke ibu ma na-adịgide adịgide n'ime ndị oke ibu ma ọ bụ ndị buru oke ibu
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Na-ebelata ihe nrịbama ihe ize ndụ nke obi dịka ọbara mgbali elu na mbufụt
Site na profaịlụ nchekwa dị mma yana uru metabolic sara mbara, Semaglutide abụrụla GLP-1 RA nke mbụ na ọrịa shuga na ọgwụgwọ oke ibu. Ụdị API anyị na-edobe nguzosi ike n'ezi ihe dị elu yana ọkwa adịghị ọcha dị ala (≤0.1% adịghị ọcha nke HPLC na-amaghị), na-eme ka nkwụsi ike nke ọgwụ dị mma.
