Tadalafil 171596-29-5 iji gwọọ Dysfunction Dysfunction na ụmụ nwoke

Tadalafil (tadalafil, tadalafil) nwere usoro molecular nke c22H1O4O4 na oke molecular arọ nke 389.4. A na-ejikarị ya na ọgwụgwọ nke ụmụ nwoke na-emegharị eme ihe kemgbe 2003, na aha azụmahịa Cialis (Cialis). Na June 2009, FDA kwadoro tadalafil na United States maka ọgwụgwọ nke ndị ọrịa nwere ọrịa purnomary arterrational (pah) n'okpuru aha azụmahịa Adcurma. A webatara tadalafil na 2003 dika ogwu maka ọgwụgwọ nke ed. Ọ na-ewe ihe dị ka nkeji iri atọ mgbe ọ ga-enwerịrị nchịkwa, mana nsonaazụ ya kachasị mma bụ 2H mgbe mmalite nke ihe, mmetụta ahụ nwere ike ịdịru maka 36h, na nri anaghị emetụta ya. Dose nke tadalafil bụ afọ 10 ma ọ bụ 20 mg, a tụrụ aro ya bụ 10 mg, a na-agbanwegharị ya dịka nzaghachi nzaghachi onye ọrịa na mmeghachi omume ọjọọ ndị ọrịa. Ọmụmụ nke tupu ahịa egosipụtara na mgbe ụlọ ọrụ nke 10 ma ọ bụ iri abụọ gachara maka izu 12, ọnụego dị mma bụ 67% na 81%, n'otu n'otu. Ọtụtụ nnyocha egosila na tadalafil nwere arụmọrụ ka mma na ọgwụgwọ Ed.

Dysfunction Dysfunction: tadalafil bụ ụdị phosphoder phosphodersase 5 (PDE5) dị ka Sildenafil, mana ihe owuwu ya dị iche na nke ikpeazụ, na nri na-eri nri anaghị egbochi ya. N'okpuru ime mkpali nke mmekọahụ, Nitric Oxi Sinshase (NS) na mkpụrụ ndụ akwara na-ahụ maka njikọta oxide (mba) site na mkpụrụ L-Argentinine. Ọ dịghị eme ka ọgwụ GunyLate na -aga, nke na-agbanwe Guanosine Tranosphate Gulic guanosine na cellclic guasa na mkpụrụ ndụ calphosine na-eme ka ikuku na-efe efe na-apụta n'ihi ezumike nke akwara. Phosphadeashereeasy pịpụ 5 (PDE5) mebiri emebi na ngwaahịa adịghị arụ ọrụ, na-eme amụ ahụ n'ime ala na-adịghị ike. Tadalafil na-egbochi nrụrụ nke PDE5, na-eduga na mkpokọta CGMP, nke na-adịcha mma akwara nke castrosum, na-eduga na oke perction. Ebe ọ bụ na nitrates abụghị ndị na-enye onyinye, jiri ya na tadalafil ga-abawanye ọkwa nke CGMP ma na-eduga na hypotension. Ya mere, ojiji ejikọtara ya na mmadụ abụọ ahụ bụ contraindicated na usoro ụlọ ọgwụ.

Tadalafil na-arụ ọrụ site na igbochi pude. GMP na-emebi emebi, yabụ jiri ya na nitrates nwere ike ibute oke ọbara mgbali ma mụbaa ihe ize ndụ nke synoni. Ndị na-egbochi ihe na-egbochi ihe na-egbu egbu, yana njikọta ya na rifalinin, na-eme ka ọ dịkwuo mma na-egbochi ọrịa. Ruo ugbu a, enweghị akụkọ na-egosi na nri na nri na mmanya na-egbu egbu na-emetụta ọgwụ a.