Tadalafil 171596-29-5 iji gwọọ ọrịa erectile na ụmụ nwoke

Tadalafil (Tadalafil, Tadalafil) nwere usoro ihe omimi nke C22H19N3O4 na ịdị arọ nke 389.4. A na-eji ya eme ihe n'ọtụtụ ebe n'ịgwọ ọrịa erectile nwoke kemgbe 2003, na aha ahia aha Cialis (Cialis). Na June 2009, FDA kwadoro tadalafil na United States maka ọgwụgwọ ndị ọrịa nwere ọbara mgbali elu pulmonary arterial (PAH) n'okpuru aha ahia Adcirca. Ewebata Tadalafil na 2003 dị ka ọgwụ maka ọgwụgwọ ED. Ọ na-arụ ọrụ 30 nkeji mgbe nchịkwa, ma mmetụta ya kacha mma bụ 2h mgbe mmalite nke omume, na mmetụta nwere ike ịdịru maka 36h, na mmetụta ya adịghị emetụta nri. Usoro nke tadalafil bụ 10 ma ọ bụ 20 mg, usoro mbụ akwadoro bụ 10 mg, a na-edozikwa dose ahụ dịka nzaghachi onye ọrịa na mmeghachi omume ọjọọ. Ọmụmụ ihe tupu ahịa egosila na mgbe nchịkwa ọnụ nke 10 ma ọ bụ 20 mg nke tadalafil maka izu 12, ọnụ ọgụgụ dị irè bụ 67% na 81%, n'otu n'otu. Ọtụtụ nchọpụta egosila na tadalafil nwere mmetụta dị mma na ọgwụgwọ ED.

Ngwọta erectile: Tadalafil bụ ụdị phosphodiesterase 5 (PDE5) na-ahọrọ dị ka sildenafil, ma usoro ya dị iche na nke ikpeazụ, na nri dị oke abụba anaghị egbochi ya. N'okpuru omume nke mkpali mmekọahụ, nitric oxide synthase (NOS) na njedebe akwara penile na sel endothelial vaskụla na-eme ka njikọ nke nitric oxide (NO) sitere na mkpụrụ L-arginine. Ọ BỤGHỊ na-eme ka guanylate cyclase, nke na-agbanwe guanosine triphosphate ka ọ bụrụ cyclic guanosine monophosphate (cGMP), si otú ahụ na-eme ka cyclic guanosine monophosphate na-adabere na protein kinase, na-eme ka mbelata nke ion calcium na sel anụ ahụ dị nro, na-eme ka corpus cavernosum erection na-eme n'ihi ntụrụndụ nke anụ ahụ dị nro. Ụdị phosphodiesterase 5 (PDE5) na-eweda cGMP n'ime ngwaahịa anaghị arụ ọrụ, na-eme ka amụ ghọọ ọnọdụ adịghị ike. Tadalafil na-egbochi mmebi nke PDE5, na-eduga n'ịgbakọta cGMP, nke na-eme ka ahụ dị nro nke corpus cavernosum, na-eduga n'ịrụ penile. Ebe ọ bụ na nitrates abụghị ndị na-enye onyinye, ijikọta ya na tadalafil ga-eme ka ọkwa cGMP dịkwuo elu ma na-eduga na hypotension siri ike. Ya mere, ejikọtara ọnụ eji ha abụọ eme ihe na omume ụlọ ọgwụ.

Tadalafil na-arụ ọrụ site na igbochi PDES. GMP na-eweda ala, yabụ ijikọ ya na nitrates nwere ike ime ka ọ daa oke ọbara mgbali ma mee ka ohere nke syncope dịkwuo elu. Ndị na-emepụta CY3PA4 ga-ebelata bioavailability nke tadanafil, yana nchikota rifampicin, cimetidine, erythromycin, clarithromycin, itracon, ketocon, na HVI protease inhibitors nwere ike ime ka ntinye ọbara nke ọgwụ ahụ dịkwuo mma. Ka ọ dị ugbu a, ọ nweghị akụkọ ọ bụla na-egosi na nri na mmanya na-emetụta akụkụ pharmacokinetic nke ngwaahịa a.