Vancomycin bụ ọgwụ nje glycopeptide a na-eji eme ihe maka nje bacteria
Nkọwa ngwaahịa
| Aha | Vancomycin |
| Nọmba CAS | 1404-90-6 |
| Usoro ihe omimi | C66H75Cl2N9O24 |
| Ibu arọ molekụla | 1449.25 |
| Nọmba EINECS | 215-772-6 |
| Njupụta | 1.2882 (atụmatụ siri ike) |
| Ntụgharị ntụgharị | 1.7350 (atụmatụ) |
| Ọnọdụ nchekwa | Akara akọrọ, 2-8 ° C |
Ụdị okwu
Vancomycin (baseand/orunspecifiedsalts);VANCOMYCIN;VancomycinBase;(3S,6R,7R,22R,23S,26S,36R,38aR) -3-(2-Amino-2-oxoethyl) -44-[2-O-(3-amino-2, 3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl] oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7 ,22,28,30,32-pentahydroxy-6-[[(2R) -4-methChemicalbookyl-2-(methylamino) -1-oxopentyl] amino]-2,5,24,38,39-pentaoxo-22H-8,11:18,21-Dietheno-23, 36-(iminomethano) -13,16:31,35-dimetheno-1H,16H-[1,6,9] oxadiazacyclohexadecino [4,5-m] [10,2,16] benzoxadiazacyclotetracosine-26-carboxylicacid.
Nkọwa
Vancomycin bụ ọgwụ nje glycopeptide. Usoro ya bụ ijikọ njikọ dị elu na alanylalanine na njedebe poly-terminal nke precursor peptide nke mgbidi nje bacteria na-emetụ n'ahụ, na-egbochi njikọ nke peptidoglycan macromolecular nke mejupụtara mgbidi sel nje, na-ebute mbibi nke mgbidi cell na-egbu nje bacteria. Vancomycin dị irè maka ọrịa siri ike nke nje bacteria Gram-positive kpatara, karịsịa ndị Staphylococcus aureus na-eguzogide methicillin, Staphylococcus epidermidis, na Enterococcus na-eguzogide ọgwụ nje ndị ọzọ ma ọ bụ na-adịghị mma.
Ngosipụta
Ọ na-ejedebe na ọrịa sistemu nke methicillin na-eguzogide Staphylococcus aureus (MRSA) na ọrịa eriri afọ na ọrịa sistemu nke Clostridium difficile kpatara; Ndị ọrịa penicillin na-enwe nfụkasị ahụ enweghị ike iji penicillins ma ọ bụ cephalosporins na ndị ọrịa nwere nnukwu ọrịa staphylococcal, ma ọ bụ ndị nwere nnukwu ọrịa staphylococcal bụ ndị na-anabataghị ọgwụ nje ndị a dị n'elu, enwere ike iji vancomycin mee ihe. A na-ejikwa ngwaahịa a maka ọgwụgwọ nke Enterococcus endocarditis na Corynebacterium (diphtheria-like) endocarditis na ndị mmadụ na-enwe nfụkasị penicillin. Ọgwụgwọ nke staphylococcus butere ọrịa arteriovenous shunt n'ime ndị ọrịa hemodialysis nwere nfụkasị penicillin na ndị na-adịghị ahụ nfụkasị penicillin.
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