Atosiban Acetate ejiri mee ihe maka ịmụ nwa oge
Nkọwa ngwaahịa
| Aha | Atosiban |
| Nọmba CAS | 90779-69-4 |
| Usoro ihe omimi | C43H67N11O12S2 |
| Ibu arọ molekụla | 994.19 |
| Nọmba EINECS | 806-815-5 |
| Ebe esi nri | 1469.0± 65.0 Celsius C (buru amụma) |
| Njupụta | 1.254±0.06 g/cm3 (buru amụma) |
| Ọnọdụ nchekwa | -20°C |
| Solubility | H2O: ≤100 mg/mL |
Nkọwa
Atosiban acetate bụ polypeptide cyclic nke jikọtara disulfide nke nwere amino acid 9. Ọ bụ molecule oxytocin gbanwetụrụ na ọnọdụ 1, 2, 4 na 8. N-terminus nke peptide bụ 3-mercaptopropionic acid (thiol na The sulfhydryl group of [Cys] 6 na-eme njikọ disulfide), C-terminal dị n'ụdị amide, amino acid nke abụọ gbanwere na N-terminal. [D-Tyr (Et)] 2, na atosiban acetate na-eji na ọgwụ dị ka mmanya Ọ dị n'ụdị nnu acid, nke a na-akpọkarị atosiban acetate.
Ngwa
Atosiban bụ oxytocin na vasopressin V1A jikọtara ndị na-anabata ndị na-anabata ya, onye na-anabata oxytocin dị ka onye na-anabata vasopressin V1A. Mgbe a na-egbochi onye na-anabata oxytocin, oxytocin ka nwere ike ime ihe site na onye na-anabata V1A, n'ihi ya, ọ dị mkpa igbochi ụzọ abụọ dị n'elu n'otu oge, na otu mmegide nke otu onye na-anabata ya nwere ike igbochi nkwụsị nke akpanwa nke ọma. Nke a bụkwa otu n'ime isi ihe kpatara agonists β-receptor, calcium channel blockers na prostaglandin synthase inhibitors enweghị ike igbochi mmachi uterine nke ọma.
Mmetụta
Atosiban bụ onye na-anakọta antagonist nke oxytocin na vasopressin V1A, usoro kemịkalụ ya yiri nke abụọ ahụ, ọ nwekwara mmekọrịta dị elu maka ndị na-anabata ya, ma na-asọmpi na oxytocin na vasopressin V1A receptors, si otú ahụ na-egbochi ụzọ ọrụ nke oxytocin na vasopressin na ibelata nkwụsị nke uterine.
