Carbetocin iji gbochie mgbochi nke akpanwa na ọbara ọgbụgba mgbe ọmụmụ
Nkọwa ngwaahịa
| Aha | CARBETICIN |
| Nọmba CAS | 37025-55-1 |
| Usoro ihe omimi | C45H69N11O12S |
| Ibu molekụla | 988.17 |
| Nọmba EINECS | 253-312-6 |
| Ntughari pụrụ iche | D -69.0° (c = 0.25 na 1M acetic acid) |
| Ebe esi nri | 1477.9± 65.0 Celsius C (buru amụma) |
| Njupụta | 1.218±0.06 g/cm3 (buru amụma) |
| Ọnọdụ nchekwa | -15°C |
| Ụdị | ntụ ntụ |
Ụdị okwu
BUTYRYL-TYR(ME) -ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS);BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT;(BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT;(BUTYRYL1, TYR(ME)2)-OXYTOCIN;(BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT;CARBETICIN;CARBETOCINTRIFLUOROACETATESALT;(2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Ọrụ ndu
Carbetocin, ihe analọgụ oxytocin (OT), bụ agonist oxytocin receptor agonist nwere Ki nke 7.1 nM.Carbetocin nwere njikọ dị elu (Ki = 1.17 μM) maka chimeric N-terminus nke onye na-anabata oxytocin.Carbetocin nwere ikike maka nyocha ọbara ọgbụgba mgbe ọmụmụ.Carbetocin nwere ike banye n'ime ihe mgbochi ụbụrụ-ọbara ma nwee ọrụ antidepressant-dị ka ọrụ site na ịgbalite ndị na-anabata oxytocin na CNS.
Ọrụ
Carbetocin bụ analọg oxytocin 8-peptide na-eme ogologo oge na-arụ ọrụ nke nwere akụrụngwa agonist, yana akụrụngwa ụlọ ọgwụ na ọgwụ ya yiri nke oxytocin na-eme n'okike.Dị ka oxytocin, carbetocin na-ejikọta ya na ndị na-anabata hormone nke akwara dị nro nke uterine, na-eme ka ọkpụkpụ rhythmic nke akpanwa, na-amụba ugboro ugboro na ụda uterine na-adabere na nkwụsị nke mbụ.Ọkwa ndị na-anabata oxytocin na akpanwa dị ala na steeti adịghị ime, mmụba n'oge ime, na ọnụ ọgụgụ kasị elu n'oge ọrụ.Ya mere, carbetocin enweghị mmetụta ọ bụla na akpanwa na-adịghị ime, ma ọ na-enwe mmetụta dị ike nke uterine contractile na akpanwa dị ime na akpanwa nke emepụtara ọhụrụ.
Gbanwee njikwa
A na-achịkwa mgbanwe dịka usoro ahụ si dị.Dabere na mmetụta na ihe egwu na ịdị njọ, a na-ekewa mgbanwe dị ka Major, Minor na saịtị.Mgbanwe saịtị nwere ntakịrị mmetụta na nchekwa na ịdịmma ngwaahịa, ya mere ọ dịghị mkpa nkwado na ngosi nye onye ahịa;Obere mgbanwe nwere mmetụta agafeghị oke na nchekwa na ịdịmma ngwaahịa, yana mkpa ịkọrọ onye ahịa;Nnukwu mgbanwe nwere mmetụta dị elu na nchekwa na ịdịmma ngwaahịa, yana mkpa nkwado nke onye ahịa.
Dịka usoro ahụ si dị, njikwa mgbanwe na-amalite site na ngwa mgbanwe nke nkọwa nkọwa na ezi uche maka mgbanwe ahụ na-akọwa.A na-eme nyocha ahụ na-eso ngwa ngwa ahụ, nke a na-eme site na njikwa mgbanwe ngalaba dị mkpa.Ka ọ dị ugbu a, a na-ekewa njikwa mgbanwe n'ime nnukwu ọkwa, ọkwa izugbe na ọkwa nta.Mgbe nlebanya kwesịrị ekwesị yana nhazi ọkwa, njikwa mgbanwe ọkwa niile kwesịrị ịkwado QA Manager.A na-eme njikwa mgbanwe mgbe nkwado dị ka atụmatụ mmemme siri dị.A na-emechi njikwa mgbanwe ahụ mgbe QA kwadoro njikwa mgbanwe ahụ nke ọma.Ọ bụrụ na metụtara ọkwa onye ahịa, a ga-agwa onye ahịa n'oge ka akwadochara njikwa mgbanwe
