Carbetocin iji gbochie mgbochi nke akpanwa na ọbara ọgbụgba mgbe ọmụmụ
Nkọwa ngwaahịa
| Aha | CARBETICIN |
| Nọmba CAS | 37025-55-1 |
| Usoro ihe omimi | C45H69N11O12S |
| Ibu arọ molekụla | 988.17 |
| Nọmba EINECS | 253-312-6 |
| Ntughari pụrụ iche | D -69.0° (c = 0.25 na 1M acetic acid) |
| Ebe esi nri | 1477.9±65.0C (buru amụma) |
| Njupụta | 1.218±0.06 g/cm3 (buru amụma) |
| Ọnọdụ nchekwa | -15°C |
| Ụdị | ntụ ntụ |
Ụdị okwu
BUTYRYL-TYR(ME) -ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; CARBETICIN; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Ọrụ ndu
Carbetocin, analog oxytocin (OT), bụ agonist oxytocin receptor agonist nwere Ki nke 7.1 nM. Carbetocin nwere njikọ dị elu (Ki = 1.17 μM) maka chimeric N-terminus nke onye na-anabata oxytocin. Carbetocin nwere ike ime nchọpụta ọbara ọgbụgba mgbe ọmụmụ. Carbetocin nwere ike banye n'ime ihe mgbochi ụbụrụ-ọbara ma nwee ọrụ antidepressant-dị ka ọrụ site na ịgbalite ndị na-anabata oxytocin na CNS.
Ọrụ
Carbetocin bụ analọg oxytocin 8-peptide na-eme ogologo oge na-arụ ọrụ nke nwere akụrụngwa agonist, yana akụrụngwa ụlọ ọgwụ na ọgwụ ya yiri nke oxytocin na-eme n'okike. Dị ka oxytocin, carbetocin na-ejikọta ya na ndị na-anabata hormone nke akwara dị nro nke uterine, na-eme ka ọkpụkpụ rhythmic nke akpanwa, na-amụba ugboro ugboro na ụda uterine na-adabere na nkwụsị nke mbụ. Ọkwa ndị na-anabata oxytocin dị na akpanwa dị ala na steeti adịghị ime, mmụba n'oge ime, na ọnụ ọgụgụ kasị elu n'oge ọrụ. Ya mere, carbetocin enweghị mmetụta ọ bụla na akpanwa na-adịghị ime, ma ọ na-enwe mmetụta dị ike nke uterine contractile na akpanwa dị ime na akpanwa nke emepụtara ọhụrụ.
Gbanwee njikwa
A na-achịkwa mgbanwe dịka usoro ahụ si dị. Dabere na mmetụta na ihe egwu na ịdị njọ, a na-ekewa mgbanwe dị ka Major, Minor na saịtị. Mgbanwe saịtị nwere ntakịrị mmetụta na nchekwa na ịdịmma ngwaahịa, ya mere ọ dịghị mkpa nkwado na ngosi nye onye ahịa; Obere mgbanwe nwere mmetụta agafeghị oke na nchekwa na ịdịmma ngwaahịa, yana mkpa ịkọrọ onye ahịa; Nnukwu mgbanwe nwere mmetụta dị elu na nchekwa na ịdịmma ngwaahịa, yana mkpa nkwado nke onye ahịa.
Dị ka usoro ahụ si dị, njikwa mgbanwe na-amalite site na ngwa mgbanwe nke nkọwa mgbanwe na ezi uche maka mgbanwe ahụ na-akọwa. A na-eme nyocha ahụ na-eso ngwa ngwa, nke a na-eme site na njikwa mgbanwe na ngalaba ndị dị mkpa. Ka ọ dị ugbu a, a na-ekewa njikwa mgbanwe n'ime nnukwu ọkwa, ọkwa izugbe na ọkwa nta. Mgbe nlebachara kwesịrị ekwesị yana nhazi ọkwa, njikwa mgbanwe ọkwa niile kwesịrị ịkwado site n'aka onye njikwa QA. A na-eme njikwa mgbanwe ahụ mgbe nkwado dị ka atụmatụ mmemme siri dị. A na-emechi njikwa mgbanwe ahụ mgbe QA kwadoro njikwa mgbanwe ahụ nke ọma. Ọ bụrụ na metụtara ọkwa onye ahịa, a ga-agwa onye ahịa n'oge ka akwadochara njikwa mgbanwe
