Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Ngwa nyocha:
Ngwakọta a bụ ihe eji emepụta lysine na-echebe, arụ ọrụ nke ejiri mee ihe na njikọ peptide na mmepe conjugate ọgwụ. Ọ na-egosipụta otu Fmoc maka nchebe N-ọnụ, yana mgbanwe n'akụkụ ya na Eic (OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), na AEEA (aminoethoxyethoxyacetate). Emebere ihe ndị a iji mụọ mmetụta lipidation, kemistri spacer, na mwepụta ọgwụ a na-achịkwa. A na-enyocha ya nke ọma n'ihe gbasara atụmatụ prodrug, ADC linkers na peptides na-emekọrịta ihe.

Ọrụ:
Fmoc-L-Lys [Eic(OtBu) -γ-Glu(OtBu) -AEEA] -OH na-eje ozi dị ka ngọngọ ụlọ maka synthesize lipid-gbanwetụrụ peptides ma ọ bụ usoro nnyefe ọgwụ. Akụkụ Eic na-eme ka lipophilicity na njikọta akpụkpọ ahụ dịkwuo mma; γ-Glu na-agbakwụnye nkwụsi ike nke enzymatic na ike ezubere iche; na AEEA na-arụ ọrụ dị ka njikọ hydrophilic na-agbanwe agbanwe. Na ọnụ, ha na-enyere iwu nke peptides na nkwalite ekwentị mkpali, ogologo ndụ ọkara ndụ, na saịtị-kpọmkwem nnyefe Njirimara.