Daptomycin 103060-53-3 maka Ọrịa Na-efe efe
Nkọwa ngwaahịa
| Aha | Daptomycin |
| Nọmba CAS | 103060-53-3 |
| Usoro ihe omimi | C72H101N17O26 |
| Ibu molekụla | 1620.67 |
| Nọmba EINECS | 600-389-2 |
| Ebe mgbaze | 202-204 Celsius C |
| Ebe esi nri | 2078.2± 65.0 Celsius C (buru amụma) |
| Njupụta | 1.45±0.1 g/cm3 (buru amụma) |
| ebe mgbari | 87 ℃ |
| Ọnọdụ nchekwa | E mechiri ya na nkụ, chekwaa ya na friza, n'okpuru -20 Celsius |
| Solubility | Methanol: soluble 5mg/ml |
| Ọnụọgụ acidity | (pKa) 4.00± 0.10 (buru amụma) |
| Ụdị | ntụ ntụ |
| Agba | agba na-ada ada odo |
Ụdị okwu
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-] -cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp- Gly-D-Ser-[(3R) -3-methyl-L-Glu-] -4- (2-aminophenyl) -4-oxo-L-Abu-]; N-[N-Decanoyl-L-Trp- D-Asn-L-Asp-] -cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L- Glu-] -3- (2-aminobenzoyl) -L-Ala-]; N- (1-Oxodecyl) -L-tryptophyl-D-asparaginyl-L-a-aspartyl-L-threonylglycyl-L-ornithinyl-L- α-aspartyl-D-alanyl-L-a-aspartylglycyl-D-seryl-(3R) -3-methyl-L-a-glutamyl-a,2-diamino-γ-oxo-benzenebutanoicacid (13-4) lactone; DAPTOMYCINE; Dapcin; Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Nkọwa
Ọgwụ daptomycin bụ ọgwụ nje cyclic lipopeptide nke nwere usoro ọhụrụ ewepụtara na broth gbaa ụka nke Streptomyces (S. reseosporus), nke na-egbochi biosynthesis nke mgbidi cell peptidoglycan site na ịkpaghasị ibufe amino acid na akpụkpọ ahụ cell.Ịgbanwe njirimara nke akpụkpọ ahụ cytoplasmic nwere ike ịkpaghasị ọrụ akpụkpọ ahụ nje bacteria n'ọtụtụ ụzọ ma gbuo nje bacteria dị mma ngwa ngwa.Na mgbakwunye na ikike ya ime ihe n'ọtụtụ nje bacteria bara uru gram-positive, daptomycin dị mkpa maka ụdị dịpụrụ adịpụ nke gosipụtara iguzogide methicillin, vancomycin, na linezolid in vitro.Ọ nwere ọrụ dị ike, yana ihe onwunwe a nwere mmetụta ụlọ ọgwụ dị mkpa maka ndị ọrịa nwere ọrịa siri ike.Eosinophilic pneumonia bụ ọrịa na-adịghị ahụkebe ma dị oke njọ nke nwere mgbaàmà gụnyere ahụ ọkụ, ụkwara, mkpụmkpụ ume, na iku ume.
Mmetụta Antibacterial
Daptomycin nwere ezigbo ọrụ bacteriostatic megide nje bacteria dị iche iche na-eguzogide ọgwụ, dị ka MIC=0.06-0.5 μg/ml maka Staphylococcus aureus na-eguzogide methicillin (MRSA), na Staphylococcus aureus na-eguzogide methicillin (MRSA).MIC = 0.0625 ~ 1μg / ml maka nje bacteria, MIC = 0.12 ~ 0.5μg / ml maka Staphylococcus epidermidis na-eguzogide oxacillin, MIC = 2.5μg / ml maka enterococcus nke na-eguzogide ọgwụ nje aminoglycoside, MIC = 2.5μg / ml maka Gmr Enterococcus bụ 0.5 ~ 1 μg / ml, na MIC nke Enterococcus na-eguzogide ọgwụ nje glycopeptide bụ 1-2 μg / ml.
