Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Ngwa nyocha:
Ngwakọta a bụ ihe lysine emezigharịrị eji eme ihe na njikọ peptide, ọkachasị maka imepụta conjugates peptide ezubere iche ma ọ bụ multifunctional. Otu Fmoc na-enye ohere maka njikọ nzọụkwụ site na Fmoc solid-phase peptide synthesis (SPPS). A na-eji ihe nrụpụta stearic acid (Ste), γ-glutamic acid (γ-Glu), na njikọ AEEA abụọ (aminoethoxyethoxyethoxyacetate), nke na-enye hydrophobicity, njikwa ụgwọ, na oghere mgbanwe. A na-amụkarị ya maka ọrụ ya na sistemụ nnyefe ọgwụ, gụnyere antibody-drug conjugates (ADCs) na peptides na-abanye cell.

Ọrụ:
Fmoc-L-Lys [Ste(OtBu)-γ-Glu(OtBu) -AEEA-AEEA] -OH na-arụ ọrụ dị ka ihe mgbochi ụlọ maka ịmepụta peptides nwere ogologo agbụ ma ọ bụ ogige njikọ ọgwụ. Stearic acid na-eme ka akpụkpọ ahụ dịkwuo mma, γ-Glu na-eme ka nkwụsi ike na nkwụsi ike nke enzymatic, na ndị na-ejikọta AEEA na-enye solubility na mgbanwe nhazi. Ọnụ, njirimara ndị a na-eme ka ogige ahụ baa uru n'ichepụta peptides maka nkwalite bioavailability, ntọhapụ a na-achịkwa, yana ngwa nnyefe ezubere iche.