Ganirelix Acetate Peptide API
Nkọwa ngwaahịa
| Aha | Ganirelix acetate |
| Nọmba CAS | 123246-29-7 |
| Usoro ihe omimi | C80H113ClN18O13 |
| Ibu arọ molekụla | 1570.34 |
Ụdị okwu
Ac-DNal-DCpa-DPal-Ser-Tyr-DHar (Et2) -Leu-Har (Et2) -Pro-DAla -NH2; Ganirelixum;ganirelix Acetate; GANIRELIX; Ganirelix Acetate USP/EP/
Nkọwa
Ganirelix bụ ogige decapeptide sịntetik, na nnu acetate ya, Ganirelix acetate bụ onye na-anabata homonụ na-ahapụ gonadotropin (GnRH). Usoro amino acid bụ: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro-D- Ala-NH2. N'ụzọ bụ isi na ụlọ ọgwụ, a na-eji ya na ụmụ nwanyị na-enye aka na teknụzụ ịmụ nwa na-achịkwa mmemme mkpali ovarian iji gbochie ọnụ ọgụgụ hormone luteinizing na-akaghị aka na ịgwọ nsogbu ọmụmụ n'ihi nke a. Ọgwụ ahụ nwere njirimara nke mmeghachi omume na-adịghị mma, ọnụ ọgụgụ dị elu nke ime ime na oge ọgwụgwọ dị mkpirikpi, ma nwee uru doro anya ma e jiri ya tụnyere ọgwụ ndị yiri ya na omume ụlọ ọgwụ.
Ihe omume ọgwụ
Mwepụta pulsatile nke gonadotropin na-ahapụ homonụ (GnRH) na-akpali njikọ na nzuzo nke LH na FSH. Ugboro nke mmụgharị LH n'etiti etiti na ngwụcha oge follicular bụ ihe dịka 1 kwa elekere. Mmụba ndị a na-egosipụta na ịrị elu na-adịru nwa oge na serum LH. N'ime etiti oge ịhụ nsọ, nnukwu mwepụta nke GnRH na-ebute mmụba nke LH. Ịwa ahụ LH etiti oge ịhụ nsọ nwere ike ịkpalite ọtụtụ nzaghachi anụ ahụ, gụnyere: ovulation, oocyte meiotic resumption, na nhazi corpus luteum. Nhazi nke corpus luteum na-eme ka ọkwa nke progesterone serum na-ebili, ebe ọkwa estradiol dara. Ganirelix acetate bụ onye na-emegide GnRH nke na-asọ mpi na-egbochi ndị na-anabata GnRH na pituitary gonadotrophs na ụzọ ntụgharị na-esote. Ọ na-emepụta mgbochi ngwa ngwa, nke na-agbanwe agbanwe nke gonadotropin secretion. Mmetụta mgbochi nke ganirelix acetate na nzuzo pituitary LH siri ike karịa nke ahụ na FSH. Ganirelix acetate emeghị ka mwepụta nke mbụ nke gonadotropins endogenous, na-emegide mmegide. Ngwọta zuru oke nke ọkwa pituitary LH na FSH mere n'ime awa 48 ka a kwụsịrị ganirelix acetate.
