Linaclotide maka eriri afọ 851199-59-2
Nkọwa nke ngwaahịa
| Aha | Linaclotide |
| Nọmba | 851199-59-2 |
| Molular | C59H79N15O21S6 |
| Molular ibu | 1526.74 |
Myiri
Linaclotide; Linaclotide; linalotidesate; linalotide; Cystelotine; L-Cystessindine-L-Cystyl-L-Tyrosli -L -l-cysteyl-l-cyparayinyl-l-cystenyl-l-cycleyll-l-cycleyl-, cyclic (1 → 10)
Nkowa
Lineclotide, ihe owuwu peptinotic nwere, actino acid 14, a na-eme ka ọgwụ GDA na-enweghị atụ na-akpasu iwe na afọ ntabi anya (cic) na ndị okenye.
Ngwongwo kemịkalụ
Linaclotide bụ ntụ ntụ na-acha ọcha. Mpempe ọnya na mmiri na mmiri sodium chloride nke ọma (0.9%).
Otu esi arụ ọrụ
Linaclotide bụ GunyLase Cyclase-C reneptor Agonist (GCCA) yana ọrụ ndị na-ahụ anya na usoro nyocha. Mahaclotide na metabolite ya na-arụ ọrụ nwere ike ibelata cyclase-c (gc-c) receato na elu ala nke obere eriri afọ. In animal models, linaclotide reduces visceral pain and increases gastrointestinal transit through activation of GC-C, and in humans, the drug also increases colonic transit. Nsonaazụ nke GC-C ọrụ na-abawanye intacellular na nke exMP (Cyclic guophosine monophosine). Enwere ike belata cgmp nwere ike belata ọrụ nke akwara mgbu na-egbutu mgbu Visceral mgbu na anụmanụ. CGMP CGMP nwere ike iwelie nkpuchi nke chloride na obere eriri afọ site na-arụ ọrụ na-eduzi ihe nzuzo nke eriri afọ na ọsọ nke obere eriri afọ.
Ajụjụ
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