Linaclotide maka Ọrịa Gastrointestinal 851199-59-2
Nkọwa ngwaahịa
| Aha | Linaclotide |
| Nọmba CAS | 851199-59-2 |
| Usoro ihe omimi | C59H79N15O21S6 |
| Ibu arọ molekụla | 1526.74 |
Ụdị okwu
Linaclotide, Linaelotide Acetate, Linaelotide, CY-14, Liclotide, Argpessin, L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13) -tris (disulfide)
Nkọwa
Linaclotide, ihe owuwu peptide synthetic nke nwere amino acid 14, metụtara ezinụlọ guanosine peptide endogenous na ọ bụ naanị FDA-akwadoro GC-C (guanylate) Cyclase-C) ọgwụ agonist maka ọgwụgwọ ọrịa obi mgbakasị ahụ na afọ ntachi (IBS-C) na afọ ntachi na-adịghị ala ala na ndị okenye (Cyclase-C).
Njirimara kemịkalụ
Linaclotide bụ ntụ ntụ amorphous na-acha ọcha na-acha ọcha; soluble ntakịrị n'ime mmiri yana ngwọta sodium chloride aqueous (0.9%).
Ka o si arụ ọrụ
Linaclotide bụ guanylate cyclase-C agonist receptor (GCCA) nke nwere ma analgesic visceral na endocrine ọrụ. Ma linaclotide na metabolite ya na-arụ ọrụ nwere ike jikọta na guanylate cyclase-C (GC-C) onye na-anabata ya n'elu luminal nke obere epithelium eriri afọ. N'ụdị anụmanụ, linaclotide na-ebelata ihe mgbu visceral ma na-abawanye transit nke eriri afọ site na ịgbalite GC-C, na n'ime mmadụ, ọgwụ ahụ na-amụbakwa transit colonic. Nsonaazụ nke ịgbalite GC-C na-abawanye ụbara intracellular na extracellular cGMP (cyclic guanosine monophosphate). Extracellular cGMP nwere ike ibelata ọrụ nke eriri akwara mgbu ma belata ihe mgbu visceral na anụmanụ ihe atụ. Intracellular cGMP nwere ike ịbawanye nzuzo nke chloride na bicarbonate na eriri afọ site na ịgbalite CFTR (cystic fibrosis transmembrane conductance regulator), nke na-emecha na-eduga n'ịbawanye nke obere mmiri mmiri nke eriri afọ na ọsọ nke obere eriri afọ.
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