Ngwa nri ọgwụ
-
Fmoc-Lys(Pal-Glu-OtBu) -OH
Fmoc-Lys(Pal-Glu-OtBu) -OH bụ mgbochi amino acid lipidated pụrụ iche emebere maka njikọkọ peptide-lipid. Ọ na-egosipụta lysine na-echebe Fmoc nwere eriri akụkụ palmitoyl-glutamate, na-eme ka akpụkpọ ahụ dịkwuo mma na bioavailability.
-
Fmoc-His-Aib-OH
Fmoc-His-Aib-OH bụ ngọngọ ụlọ dipeptide eji na peptide synthesis, na-ejikọta Fmoc-echebe histidine na Aib (α-aminoisobutyric acid). Aib na-ewebata conformational rigidity, na-eme ka ọ bara uru maka imepụta peptides helical na kwụsiri ike.
-
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
Boc-His (Trt) -Aib-Glu (OtBu) - Gly-OH bụ mpempe tetrapeptide echedoro nke ejiri na njikọ peptide na mmepe ọgwụ. Ọ nwere otu arụrụ arụ echekwabara nke ọma maka ijikọ na njiri mara Aib (α-aminoisobutyric acid) iji kwalite nkwụsi ike helix na nkwụsi ike.
-
Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU bụ molekul njikọ lipidated synthetic emebere maka nnyefe ọgwụ ezubere iche yana mgbochi-ọgwụ conjugates (ADCs). Ọ nwere ọdụ stearoyl (Ste) hydrophobic, γ-glutamyl ezubere iche motif, AEEA spacers maka mgbanwe, yana otu OSu (NHS ester) maka njikọta nke ọma.
-
Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH bụ ngọngọ ihe eji echekwa ihe eji eme ihe na-egosi α-methylated leucine, nke a na-ejikarị eme ihe n'ichepụta ọgwụ peptide iji kwalite nkwụsi ike nke metabolic na nhọrọ nnabata.
-
Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) bụ ihe nchacha zwitterionic sịntetị nke a na-ejikarị na nyocha protein membrane na usoro ihe omimi, ọkachasị na NMR spectroscopy na crystallography.
-
Donidalorsen
Donidalorsen API bụ antisense oligonucleotide (ASO) na-enyocha nyocha maka ọgwụgwọ angioedema eketa (HAE) na ọnọdụ mkpali metụtara ya. A na-amụ ya na usoro ọgwụgwọ ezubere iche maka RNA, na-achọ ibelata okwu nkeplasma prekallikrein(KLKB1 mRNA). Ndị na-eme nchọpụta na-eji Donidalorsen chọpụta usoro ịgbachi nkịtị n'ime mkpụrụ ndụ ihe nketa, ọgwụ ọgwụ na-adabere na dose, na njikwa ogologo oge nke mbufụt mgbasa ozi bradykinin.
-
Fitusiran
Fitusiran API bụ RNA (siRNA) nke na-etinye aka na-arụ ọrụ nke a nyochara nke ọma na ngalaba hemophilia na ọrịa coagulation. Ọ lekwasịrị anyaantithrombin (AT ma ọ bụ SERPINC1)mkpụrụ ndụ ihe nketa na imeju iji belata mmepụta antithrombin. Ndị na-eme nchọpụta na-eji Fitusiran nyochaa usoro nnyonye anya RNA (RNAi), ịgbachi nkịtị n'ime imeju, yana usoro ọgwụgwọ ọhụụ maka ịhazigharị coagulation na ndị ọrịa hemophilia A na B, yana ma ọ bụ na-enweghị ihe mgbochi.
-
Givosiran
Givosiran API bụ RNA (siRNA) nke na-etinye aka na ya nke a na-amụ maka ọgwụgwọ nke nnukwu imeju porphyria (AHP). Ọ kpọmkwem lekwasịrị anya naALAS1gene (aminolevulinic acid synthase 1), nke na-etinye aka na heme biosynthesis ụzọ. Ndị na-eme nchọpụta na-eji Givosiran nyochaa nnyonye anya RNA (RNAi), usoro ọgwụgwọ na-adabere na imeju, na imeju nke ụzọ metabolic na-etinye aka na porphyria na ọrịa mkpụrụ ndụ ihe nketa metụtara ya.
-
Plozasiran
Plozasiran API bụ obere RNA (siRNA) nke na-etinye aka na ya emebere maka ọgwụgwọ hypertriglyceridemia na ọrịa obi na ọrịa metabolic metụtara ya. Ọ lekwasịrị anyaAPOC3mkpụrụ ndụ ihe nketa, nke na-etinye koodu apolipoprotein C-III, bụ isi na-achịkwa metabolism triglyceride. N'ime nyocha, a na-eji Plozasiran mụọ usoro mgbada lipid dabere na RNAi, nkọwapụta mkpụrụ ndụ ihe nketa, yana ọgwụgwọ ogologo oge maka ọnọdụ dị ka ọrịa chylomicronemia nke ezinụlọ (FCS) na dyslipidemia agwakọta.
-
Zilebesiran
Zilebesiran API bụ nyocha obere RNA (siRNA) na-etinye aka na nyocha nke emepụtara maka ọgwụgwọ ọbara mgbali elu. Ọ lekwasịrị anyaAGTmkpụrụ ndụ ihe nketa, nke na-etinye koodu angiotensinogen - akụkụ bụ isi nke sistemu renin-angiotensin-aldosterone (RAAS). Na nyocha, a na-eji Zilebesiran amụ usoro ịgbachi nkịtị maka mkpụrụ ndụ ọbara mgbali elu ogologo oge, teknụzụ nnyefe RNAi, yana ọrụ sara mbara nke ụzọ RAAS na ọrịa obi na akụrụ.
-
Caspofungin maka ọrịa antifungal
Aha: Caspofungin
Nọmba CAS: 162808-62-0
Usoro ihe omimi: C52H88N10O15
Ibu ibu: 1093.31
Nọmba EINECS: 1806241-263-5
Ebe esi mmiri: 1408.1± 65.0 °C (buru amụma)
Njupụta: 1.36± 0.1 g/cm3 (buru amụma)
Ọnụọgụ acidity: (pKa) 9.86±0.26 (buru amụma)