Caspofungin maka ọrịa antifungal
Nkọwa ngwaahịa
| Aha | Caspofungin |
| Nọmba CAS | 162808-62-0 |
| Usoro ihe omimi | C52H88N10O15 |
| Ibu molekụla | 1093.31 |
| Nọmba EINECS | 1806241-263-5 |
| Ebe esi nri | 1408.1± 65.0 °C (buru amụma) |
| Njupụta | 1.36±0.1 g/cm3 (buru amụma) |
| Ọnụọgụ acidity | (pKa) 9.86±0.26 (buru amụma) |
Ụdị okwu
CS-1171; Caspofungine; CASPOFUNGIN; CASPORFUNGIN; PneuMocandinB0,1-[(4R,5S) -5-[(2-aMinoethyl) aMino] -N2- (10,12-diMethyl-1-oxotetradecyl) -4-hydroxy- L-ornithine] -5-[(3R) -3-hydroxy-L-ornithine]-; CaspofunginMK-0991; Aids058650; Aids-058650
Njirimara kemịkalụ
Caspofungin bụ echinocandin izizi akwadoro maka ọgwụgwọ ọrịa fungal na-efe efe.Nnwale in vitro na in vivo gosipụtara na caspofungin nwere ezigbo ọrụ antibacterial megide nje nje ndị dị mkpa - Candida na Aspergillus.Caspofungin nwere ike ịgbaji mgbidi cell site na igbochi njikọ nke 1,3-β-glucan.Na ụlọ ọgwụ, caspofungin nwere mmetụta dị mma na ọgwụgwọ nke candidiasis dị iche iche na aspergillosis.
Mmetụta
(1,3) -D-glucan synthase bụ isi ihe dị mkpa nke njikọ mgbidi cell fungal, na caspofungin nwere ike ịkpata mmetụta antifungal site na enweghị asọmpi na-egbochi enzyme a.Mgbe nchịkwa eriri afọ gasịrị, ntinye ọgwụ plasma na-agbada ngwa ngwa n'ihi nkesa anụ ahụ, na-esote mwepụta nke ọgwụ ahụ nke nta nke nta na anụ ahụ.Metabolism nke caspofungin na-abawanye site na ọnụọgụ na-abawanye ma na-ejikọta ya na oge iji kwụsie ike yana ọtụtụ doses.Ya mere, iji nweta ọkwa ọgwụgwọ dị irè ma zere nchịkọta ọgwụ, a ga-edozi dose mbụ nke mbụ na-esote usoro nlekọta.Mgbe ị na-eji cytochrome p4503A4 inducers n'otu oge, dị ka rifampicin, carbamazepine, dexamethasone, phenytoin, wdg, a na-atụ aro ịbawanye dose nke caspofungin.
Ngosipụta
Ihe ngosi FDA kwadoro maka caspofungin gụnyere: 1. Ahụ ọkụ na neutropenia: akọwapụtara dị ka: ahụ ọkụ> 38 ° C nwere ọnụ ọgụgụ neutrophil zuru oke (ANC) ≤500 / ml, ma ọ bụ na ANC ≤1000 / ml ma buru amụma na ọ nwere ike belata. erughị 500/ml.Dị ka ndụmọdụ nke Infectious Diseases Society of America (IDSA) si kwuo, ọ bụ ezie na a na-agwọ ndị ọrịa nwere ahụ ọkụ na-adịgide adịgide na neutropenia na ọgwụ nje dị iche iche dị iche iche, a ka na-atụ aro ndị ọrịa nwere nnukwu ihe ize ndụ ka ha jiri ọgwụgwọ antifungal empiric, gụnyere caspofungin na ọgwụ ndị ọzọ na-egbu egbu. ..2. Candidiasis invasive: IDSA na-atụ aro echinocandins (dị ka caspofungin) dị ka ọgwụ nke nhọrọ maka candidemia.Enwere ike iji ya gwọọ ọnya afọ, peritonitis na ọrịa obi nke ọrịa Candida kpatara.3. Esophageal candidiasis: Enwere ike iji Caspofungin na-agwọ ọrịa candidiasis nke esophageal na ndị ọrịa nwere nkwụsị ma ọ bụ anabataghị ọgwụgwọ ndị ọzọ.Ọtụtụ nnyocha achọpụtala na mmetụta ọgwụgwọ nke caspofungin dị ka nke fluconazole.4. Aspergillosis invasive: A kwadoro Caspofungin maka ọgwụgwọ nke aspergillosis na-emerụ ahụ na ndị ọrịa na-enwe ndidi, nguzogide, na adịghị arụ ọrụ nke isi ọgwụ antifungal, voriconazole.Otú ọ dị, a naghị atụ aro echinocandin ka ọ bụrụ ọgwụgwọ nke mbụ.
