Rapamycin bụ ọgwụ a immunosuppricepanpancepressive, mgbochi kansa na mgbochi
Nkọwa nke ngwaahịa
| Aha | Rapaamycin |
| Nọmba | 53123-88-9 |
| Molular | C51H79NO13 |
| Molular ibu | 914.19 |
| Nọmba einecs | 610-965-5 |
| Isi mmiri | 799.83 Celsius C (buru amụma) |
| Keuju | 1.0352 |
| Ọnọdụ nchekwa | Kara aka na akọrọ, chekwaa na friza, n'okpuru -20 ° C |
| Odidi | Nzu otite |
| Agba | Ucha |
| Mbukota | Akpa Pear + Aluminom akpa |
Myiri
Ay 22989; 23,27-pyrido (2H-Pycomno (1,1) oxaazacycontine; rapamicin; rapaamycin; lamycin, hygroscopicus; rpm
Mmetụta ọgwụ
Nkowa
Rapiamycin bụ ọgwụ nje Macrolide nke na-adịkarị yiri nke ịlọsa (FK00), ma enwere usoro immunosupprespressive. FK00 na-egbochi oke nke t lymphocytes site na g0 frase na fytokine na-egbochi contim na calcium n'ụzọ dị iche iche nke t na b lymphocytes. Mahadum Chicago Medical Ndị na-eme nchọpụta dị na mbadamba ụrọ na-acha akwụkwọ ndụ na-eme ka akwara ọgwụ dị iche iche dị na Europe na United States, nke nwere ike imeziwanye ọgwụ ọgwụ ndị ọzọ, si otú ahụ na-etolite nlanarị nke oge. Nnyocha e mere egosila na Rapamycin na-adị mfe debanye na enzymes mgbe ịbanyechara nri nri, nke nwere ike ịmịpụta nsonaazụ na-emebi ihe nke nri na-emebi ihe na Rapamycin. Nwere ike melite bioavailality nke rapaamycin. A na-ekwu na ndị dọkịta mbụ achọpụtala na ihe ọ theụ mkpụrụ osisi vaịn nwere mmetụta nke imeziwanye nnabata ọnụ nke shanming, na ugbu a na mba ndị Europe na-etinye ya na nkwadebe rapamycin.
N'afọ ndị na-adịbeghị anya, ọmụmụ achọpụtala na ebumnuche nke rapaamycin (MTOR) bụ Kintasellar Kinaselar, na enweghị nsogbu nke ụzọ nhazi ya nwere ike ibute ọrịa dị iche iche. Dị ka onye na-egbochi mta, Rapaamycin nwere ike ịgwọ ọnya na-enwe mmekọrịta chiri anya na ụzọ a, ọrịa ọgwụ kansa, ọrịa ọgwụ ara, ọrịa neuror na ọrịa kansa. Karịsịa na ọgwụgwọ ọrịa abụọ dị ụkọ, Lymphangyoomatosis) na tsc (nke pụtara ìhè), nsonaazụ ahụ nwekwara ike ileba anya dị ka ọrịa tumo ruo n'ókè ụfọdụ.
Mmetụta akụkụ
Rapamycin (Rapa) nwere mmetụta yiri ya na FK06. N'ọtụtụ ọnwụ, achọpụtara nsonaazụ ya dị iche iche - dabere na-agbanwe agbanwe, na rapa na NevoTonoxicity na-enweghị hyperroplasia. Isi ihe na-egbu egbu na nsonaazụ ya gụnyere: isi ọwụwa, ọgbụgbọ, nsị, imi na nkwonkwo, na nkwonkwo mgbu. Ọnọdụ ụlọ nyocha na-agụnye: thrombocytopenia, leukopenia, ọnya afọ, hyprolemia, whomalemia, wyg. Eyema nku anya na rapa A na-eche na nchịkwa plasma phosphate nke ala obere ga-enwe ogologo phosphate phospongotion site na akụrụ rapa -s. Dị ka immunosupprespresdants ndị ọzọ, Rapa nwere ohere dị ukwuu nke ọrịa, ya na ndị a kọrọ na-abawanye ụba pneudonia karị, ma ihe omume ndị ọzọ na-efe efe adịghị iche na CSA.
