Chondroitin sulfate maka ọgwụgwọ ọrịa obi, ogbu na nkwonkwo na ọgwụgwọ nke ọnya Corneal ịdị ọcha 98%
Nkọwa ngwaahịa
| Aha | Chondroitin sulfate |
| Nọmba CAS | 9007-28-7 |
| Usoro ihe omimi | C13H21NO15S |
| Ibu molekụla | 463.36854 |
| Nọmba EINECS | 232-696-9 |
| Mmiri solubility | Soluble na mmiri |
| Ịdị ọcha | 98% |
| Nchekwa | Na-echekwa na okpomọkụ mgbe niile |
| Ụdị | Ntụ ntụ |
| Agba | Na-acha ọcha na-acha ọcha |
| Nkwakọ ngwaahịa | Akpa PE+Aluminom akpa |
Ụdị okwu
poly-1 (2/3) -n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4- (6) sulfonyl-d-galactose;chondroitinpoly sulfate;chondroitin sulfates;chondroiti nsulfuric acid;chondroitin sulfuric acid;chonsurid;CSO; (5ξ) -2- (Carboxyamino) -2-deoxy-3-O-β-D-glucopyranuronosyl-4-O-sulfo-α-L-arabino-hexopyranose
Mmetụta ọgwụ
Nkọwa
Chondroitinsulfate (CS) bụ mucopolysaccharide acid nke ewepụtara ma sachaa site na anụ ahụ cartilage anụmanụ.Chondroitin sulfate nwere usoro dị iche iche dị ka A, C, D, E, H na K. Chondroitin sulfate na okike na-ahụkarị na cartilage anụmanụ, ọkpụkpụ akpịrị, ọkpụkpụ imi (41% na pigs), anụ anụ, septum inyinya na trachea (nwere. 36% ruo 39%), anụ ahụ ndị ọzọ dị ka ọkpụkpụ ụkwụ, ligaments, akpụkpọ anụ, cornea, wdg dịkwa n'ime ya.Ọdịnaya nke cartilage azụ bara ụba nke ukwuu, dịka 50% ruo 60% na ọkpụkpụ shark, yana ntakịrị ihe na anụ ahụ njikọ.
Maka ọrịa atherosclerotic nke akwara ọbara, mmụba ọbara lipids na cholesterol, arteriosclerosis, angina pectoris, ischemia myocardial ischemia, myocardial infarction, wdg na ndị ọrịa nwere ọrịa obi.
Ihe omume ọgwụ
Rapamycin (RAPA) nwere mmetụta ndị yiri ya na FK506.N'ime ọnụ ọgụgụ dị ukwuu nke ule ụlọ ọgwụ, a chọpụtara na mmetụta ya na-adabere na dose-dabere na ntụgharị, na RAPA na usoro ọgwụgwọ achọpụtaghị na ọ nwere nnukwu nephrotoxicity na enweghị hyperplasia gingival.Isi nsi na mmetụta ya gụnyere: isi ọwụwa, ọgbụgbọ, isi ọwụwa, ọbara imi, na mgbu nkwonkwo.Laboratory abnormalities gụnyere: thrombocytopenia, leukopenia, hemoglobin dị ala, hypertriglyceridemia, hypercholesterolemia, hyperglycemia, elu imeju enzymes (SGOT, SGPT), elu lactate dehydrogenase, hypokalemia, Hypomagnesemia, wdg. N'ihi na n'oge na-adịbeghị anya, RAPA na-akọrọ edema n'anya anya na nchịkwa nke RAPA dị ala. A na-eche na ọkwa phosphate plasma ga-adịte aka na mkpochapụ phosphate sitere na akụrụ ebufere site na ọgwụgwọ immunosuppressive dabeere na RAPA.Dị ka ndị ọzọ immunosuppressants, RAPA nwere ụba ohere nke ibute ọrịa, na a kọrọ na ọ na-amụba ka oyi baa karịsịa, ma omume nke ndị ọzọ ohere na-efe efe adịghị nnọọ iche na CsA.
Mmetụta Toxicological
Chondroitin sulfate dị ebe niile na anụ ahụ cartilage mmadụ na anụmanụ.Nkwadebe ọgwụ na-enwekarị isomers abụọ nke chondroitin sulfate A na chondroitin sulfate C, na ọdịnaya nke chondroitin sulfate na cartilage nke anụmanụ dị iche iche na afọ dị iche iche.Mmetụta ọgwụ ya bụ ndị a: chondroitin sulfate nwere ike wepụ lipids na lipoproteins dị n'ọbara, wepụ cholesterol n'ime arịa ọbara dị n'akụkụ obi, gbochie ma na-agwọ ọrịa atherosclerosis, na-abawanye ọnụego mgbanwe nke lipids na fatty acids na sel.Chondroitin sulfate nwere ike igbochi ma gwọọ ọrịa obi.Ọ nwere mgbochi atherosclerosis na mgbochi atherogenic plaque e guzobere mmetụta na nnwale arteriosclerosis ụdị;na-abawanye alaka akwara obi ma ọ bụ mgbasa nke atherosclerosis, ma nwee ike mee ngwangwa nnwale ọbara arteriosclerosis ma ọ bụ embolism.Ọgwụgwọ, mmeghari na mmezi nke necrosis myocardial ma ọ bụ mmebi.Ọ nwere ike ịbawanye biosynthesis nke onye ozi cell ribonucleic acid (mRNA) na deoxyribonucleic acid (DNA) ma nwee mmetụta nke ịkwalite metabolism cell.Ọrụ anticoagulant dị ala.Chondroitin sulfate nwere mmetụta anticoagulant na-agafeghị oke, yana 1 mg nke chondroitin sulfate A dabara na ọrụ anticoagulant nke 0.45U nke heparin.Ọrụ anticoagulant a anaghị adabere na antithrombin III ka ọ rụọ ọrụ ya, ọ nwere ike ịrụ ọrụ anticoagulant site na usoro fibrinogen.Chondroitin sulfate nwekwara mgbochi mkpali, accelerated ọnya ọgwụgwọ na mgbochi tumor mmetụta.
