SildenaFil cittive na-emeso ụzọ Dysfunction 171599-83-0

Arụma ihe ọmụma
Sildenafil citrate bụ nhọrọ 5-phosphodersase na-eme ka Nitric oxide - ịdabere na-adabere - ndagide gunopine-mermanite site na igbochi Guanosine guphosine monophosine. Na mgbakwunye na mmụba nke arịa ọbara osisi ọbara, ọ nwekwara ike igbochi ma ọ bụ tụgharịa vaskụla.

Njirimara ọgwụ na ngwa
Sildenafil cantrate, aha azụmahịa viagre, nke a na-akpọkarị Viagra, bụ GuyChic guanosine ụdị 5 (PDE5) na-egbochi nchịkọta ahụ. Sildenafil cantate nwere ike ịkwalite mmetụta nke nitric oxide (mba) site na igbochi ụdị 5 phosphadestrase nke na-egbochi ndị na-agba ụdọ monopsine (CGMP) na carops carenosum. Mee ka ọkwa nke CGMP na carenos corpos, na-eme ka akwara dị nro na caroprus corpos, na-abawanye na-egbu egbu, mee ka ike gwụ ya ma nwekwuo nkwụsi ike. Maka ndị ọrịa na-enweghị ike na-emegharị. Ndị okenye na-ewere oge 50 mg oge ọ bụla, ruo 1 otu ụbọchị, ma jiri ya dị ka 1 awa tupu inwe mmekọahụ. Oke kachasị dị 0.1G oge ọ bụla.

Na ọmụmụ ihe vivo
Na nkịta a na-ahụ anya, Sildenafil Cristi cristin na-eme ka percil rụọ ọrụ n'okpuru mkpali akwara akwara ọkụ site na ịtụgharị nsogbu. Sildenafil Citraved nke akara nwere nsogbu carbamoylchoylloylchoylloyl na-akpali izu ike na njigide oke nke oke bekee nke oke bekee. Na Spague-Dawley Raats, Sildenafil na-eme ka ọrụ dị mma na-arụ ọrụ na oge na-adabere na ụbọchị 28 na dose nke 20 mg / kg kwa ụbọchị. Na Sprisue-dawley oke, nchịkwa nke Sildenafil rụpụtara n 'olu na-echebe na ichekwa nchịkwa na ichebe CD31 na Inos. Na Spague-Dawley Raats, Sildenafil na-be belatara na apoptotic index ma mụbaa nke akt na EnS ma e jiri ya tụnyere ndị otu njikwa.