Sildenafil Citrate na-agwọ ọrịa erectile 171599-83-0
Nkọwa ngwaahịa
| Aha | Sildenafil Citrate |
| Nọmba CAS | 171599-83-0 |
| Usoro ihe omimi | C28H38N6O11S |
| Ibu arọ molekụla | 666.70 |
| Nọmba EINECS | 200-659-6 |
| Merck | 14,8489 |
| Njupụta | 1.445g / cm3 |
| Ọnọdụ nchekwa | 2-8 Celsius C |
| Ụdị | Ntụ ntụ |
| Agba | Ọcha |
| Mmiri solubility | DMSO:> 20mg/mL |
Ụdị okwu
Viagra, Sildenafil citrate; 1-[3- (4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4,3-d] pyrimidin-5-yl) -4-ethoxyphenyl] sulfonyl] -4-methylpiperazinecitratesalt; 5-[2-Ethoxy-5- (4-methylpiperazin-1-yl) sulfonylphenyl] -1-methyl-3-propyl-4H-pyrazolo [5,4-e] pyrimidin-7-onecitratesalt; 1-[3- (6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4,3-d] pyrimidin-5-yl) -4-ethoxyphenyl] sulfonyl] -4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate (100mg); Sildenafilcitrate,>=99%;Sildenafilcitrate,Ọkachamara; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl) sulfonyl] phenyl] -1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo [4,3-d] pyrimidin-7-onecitrate
Mmetụta ọgwụ
Ihe omume ọgwụ
Sildenafil citrate bụ 5-phosphodiesterase inhibitor na-ahọrọ nke na-eme ka nitric oxide-based, cyclic gunosine monophosphate-mediated pulmonary vasodilation site na igbochi nkwụsị nke cyclic guanosine monophosphate. Na mgbakwunye na mgbasawanye kpọmkwem nke arịa ọbara pulmonary, ọ nwekwara ike igbochi ma ọ bụ gbanwee nhazigharị vaskụla.
Njirimara ọgwụ na ngwa
Sildenafil citrate, aha ahia Viagre, nke a na-akpọkarị Viagra, bụ cyclic guanosine monophosphate (cGMP) -ụdị phosphodiesterase ụdị 5 (PDE5) inhibitor nke nwere ike ịkwalite nrụpụta mgbe nchịkwa ọnụ gasịrị. Sildenafil citrate nwere ike ịkwalite mmetụta nke nitric oxide (NO) site na igbochi ụdị 5 phosphodiesterase nke na-emepụta cyclic guanosine monophosphate (cGMP) na corpus cavernosum. Mee ka ọkwa cGMP dị na corpus cavernosum dị jụụ, mee ka ahụ ike dị nro dị na corpus cavernosum dịkwuo mma, mee ka ọbara na-abanye n'ọbara, gbatịa oge ịgbatị amụ ma mee ka ọ dịkwuo ike. Maka ndị ọrịa na-adịghị ike na-arụ ọrụ erectile. Ndị okenye na-eji ọnụ 50 mg ọnụ oge ọ bụla, ruo otu ugboro n'ụbọchị, ma jiri ya dị ka achọrọ ihe dị ka elekere 1 tupu enwe mmekọahụ. Oke kachasị bụ 0.1g kwa oge.
Na vivo ọmụmụ
N'ime nkịta aneshetized, Sildenafil citrate na-eme ka ọrụ penile erectile na-arụ ọrụ n'okpuru mkpali akwara pelvic site na ịlele nrụgide intracavernous. Sildenafil citrate n'ụzọ pụtara ìhè tụgharịrị ezumike carbamoylcholine na-adịghị mma ma gbochie nguzobe superoxide na anụ ahụ cavernosal nke oke bekee hypercholesterolemic. Na oke Sprague-Dawley, Sildenafil na-eme ka arụ ọrụ erectile dịkwuo mma n'ụzọ na-adabere na oge, na mgbake kachasị na-eme na ụbọchị 28 na dose nke 20 mg / kg kwa ụbọchị. Na oke Sprague-Dawley, nchịkwa nke Sildenafil mere ka nchekwa na nchekwa nke collagen muscle dị nro na-echekwa CD31 na eNOS okwu. Na oke Sprague-Dawley, Sildenafil belatara nke ukwuu index apoptotic ma mụbaa phosphorylation nke akt na eNOS ma e jiri ya tụnyere otu njikwa.
