Terlipressin Acetate maka ọbara ọgbụgba nke Esophageal Variceal

Terlipressin, onye aha ya bụ triglycyllysine vasopressin, bụ nkwadebe vasopressin na-eme ogologo oge. Ọ bụ ụdị prodrug, nke na-adịghị arụ ọrụ n'onwe ya. A na-eme ya site na aminopeptidase in vivo iji jiri nwayọọ "wepụta" lysine vasopressin na-arụ ọrụ mgbe ọ wepụsịrị ihe fọdụrụ glycyl atọ na N-terminus ya. Ya mere, terlipressin na-arụ ọrụ dị ka ebe nchekwa nke na-ahapụ lysine vasopressin n'otu oge.

Mmetụta ọgwụ ọgwụ nke terlipressin bụ ijikọ akwara vaskụla splanchnic dị nro ma belata mbelata ọbara ọgbụgba (dịka ibelata ọbara na mesentery, splin, akpanwa, wdg), si otú ahụ belata nrịba ọbara portal na mgbali portal. N'aka nke ọzọ, ọ nwekwara ike ibelata plasma mmetụta nke renin renin, si otú ahụ na-amụba ọbara gbasara akụrụ, na-eme ka ọrụ akụrụ dịkwuo mma na mmụba mmamịrị na ndị ọrịa nwere ọrịa hepatorenal. Terlipressin ugbu a bụ naanị ọgwụ nwere ike imeziwanye ọnụọgụ ndụ nke ndị ọrịa nwere ọbara ọgbụgba variceal esophageal. A na-eji ya eme ihe na ọgwụgwọ ụlọ ọgwụ nke variceal hemorrhage. Na mgbakwunye, ejirila terlipressin mee ihe nke ọma na imeju na akụrụ. N'ozuzu, ọ ga-abụ na ọ ga-arụ ọrụ bara uru n'ịgbakọ ihe nhụsianya refractory na resuscitation cardiopulmonary. E jiri ya tụnyere vasopressin, ọ na-enwe mmetụta na-adịgide adịgide, ọ dịghị akpata nsogbu ndị dị ize ndụ, gụnyere fibrinolysis na nsogbu siri ike na usoro obi, ma dị mfe iji (ịgba ọgwụ intravenous), nke kwesịrị ekwesị maka nlekọta dị ukwuu na nke siri ike. Nnapụta na ọgwụgwọ nke ndị ọrịa siri ike.