Tirzepatide

Nkọwa dị mkpirikpi:

Tirzepatide bụ agonist dual novel nke GIP na GLP-1 ndị na-anabata ya, nke emepụtara maka ọgwụgwọ ụdị ọrịa shuga 2 na oke ibu. Dị ka "twincretin" nke mbụ na klaasị, Tirzepatide na-eme ka mmepụta insulin dịkwuo elu, na-egbochi mwepụta glucagon, ma na-ebelata oke agụụ na ibu ahụ. Tirzepatide API anyị dị ọcha bụ nke ejikọtara na kemịkalụ, enweghị adịghị ọcha sitere na cell, ma na-ezute ụkpụrụ nchịkwa mba ụwa maka ịdịmma, nkwụsi ike, na scalability.

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API Tirzepatide
Tirzepatide bụ peptide sịntetik na-emebi emebi nke na-arụ ọrụ dị ka agonist abụọ nke ma glucose dabere insulinotropic polypeptide (GIP) na glucagon-dị ka peptide-1 (GLP-1). Ọ na-anọchi anya klaasị ọhụrụ nke usoro ọgwụgwọ dabere na incretin nke a maara dị ka “twincretins”, na-enye njikwa metabolism emelitere maka ndị ọrịa nwere ụdị ọrịa shuga 2 na oke ibu.

A na-emepụta API Tirzepatide anyị site na usoro nhazi kemịkalụ dị elu, na-ahụ na ịdị ọcha dị elu, ọkwa adịghị ọcha dị ala, yana ezigbo nhazi-na-batch. N'adịghị ka peptides sitere na rDNA, API sịntetik anyị nwere onwe ya na protein cell cell na DNA, na-eme ka biosafety na nrube isi n'usoro. Edozila usoro mmepụta ihe maka mmụba iji gboo mkpa zuru ụwa ọnụ na-eto eto.

Usoro nke Omume
Tirzepatide na-arụ ọrụ site n'otu oge na-akpali ma GIP na GLP-1 ndị na-anabata ya, na-enye mmekọ na mmetụta synergistic:

Mgbalite nnabata nke GIP: na-eme ka mmepụta insulin dịkwuo elu ma nwee ike melite mmetụta insulin.

Mgbalite nnabata GLP-1: na-egbochi mwepụta glucagon, na-egbu oge ịwụsa afọ, ma belata agụụ.

Ngwakọta ọrụ na-eduga na:

Njikwa glycemic emelitere

Mbelata arọ ahụ

Emelitere satiety ma belata oriri nri

Nyocha Clinical & Nsonaazụ
Tirzepatide egosipụtala ịdị irè na-enwetụbeghị ụdị ya n'ọtụtụ nnukwu nnwale ụlọ ọgwụ (usoro SURPASS & SURMOUNT):

Mbelata HbA1c dị elu ma e jiri ya tụnyere GLP-1 RA (dịka, Semaglutide)

Mbelata ịdị arọ ruru 22.5% na ndị ọrịa buru ibu - tụnyere ịwa ahụ bariatric n'ọnọdụ ụfọdụ

Mmetụta mmalite ngwa ngwa yana njikwa glycemic na-adịgide adịgide maka iji ogologo oge

Ihe nrịbama cardiometabolic emelitere: gụnyere ọbara mgbali elu, lipids, na mbufụt

Tirzepatide abụghị naanị na-emegharị usoro ọgwụgwọ maka ụdị ọrịa shuga 2 kama ọ na-apụta dị ka nhọrọ ọgwụgwọ bụ isi maka mbelata ibu ahụike yana ọrịa metabolic syndrome.

Ogo & nnabata
API Tirzepatide anyị:

Zute ụkpụrụ ịdịmma zuru ụwa ọnụ (FDA, ICH, EU)

A nwalere site na HPLC maka ọkwa adịghị ọcha ama ama na amaghi ama

Emepụtara n'okpuru ọnọdụ GMP nwere akwụkwọ usoro zuru oke

Na-akwado nnukwu mmepụta R&D

Nke gara aga: Semaglutide

Osote: Etelcalcetide Hydrochloride

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