VaderdDellal dihydrochloride na-eme ihe na-emeghe 224785-91-5-5

Arụma ihe ọmụma
Ọgwụ a bụ ụdị phosphoderAse 5 (PDE5) na-egbochi. Nlekọta nke ọgwụ a nwere ike ime ka ogo ya na oge nke exection, ma meziwanye ọnụ ọgụgụ nke mmekọahụ na ndị ọrịa ụmụ nwoke nwere dysfunction. Ntinye na ndozi nke oria penaction bụ ihe metụtara izu ike nke selnosal dị larịị, na cyMP gunosine (CGMP) bụ onye ogbugbo nke izu ike nke selnosal dị mma. Ọgwụ a na-egbochi nduzi nke CGMP site na igbochi ụdị phosphoder pes 5, na-eme ka mmụba nke CGMP, na njedebe nke peros. E jiri ya tụnyere phosphodhoder 1, 2, 3, 4, 4, ọgwụ a nwere ụdị ọgwụ dị elu maka ụdị 5 phosphoderanuarrase 5. Fọdụ data na-egosi na ụkpụrụ na-egbochi ya na ụdị phosphoderse kachasị mma karịa ụdị posisphoditos ndị ọzọ. Pịnye Phosphoderanuse ndị na-egbochi ndị na-emegide onwe ha.

Njirimara ọgwụ na ngwa

1. Mgbe ejiri ya na-egbochi ya (dịka Ritnovir, Indingavir, SETCONAZOLE, ọ na-abawanye na ọkara, wdg) Mgbanwe, isi ọwụwa, ihu na-agbagharị, prispism). Ekwesịrị izere ọgwụ a na ritenovavir na Indovir. Mgbe ejiri ya na erytomycin, Ketocnazole, na ITRACONAZOLE, na ITROCAZAZOLE AGHYGH CHATE 5 MG na ITROCANAZOLE na ITRACONAZOLE agaghị aga 200 mg.
2 Usoro ya nke ihe ga-abawanyeIndantta nke CGMP, na-ebute mmetụta antihypen mmetụta na-abawanye ma mụbaa obi obi. Mgbe ejiri ya na ihe mgbochi na-egbochi ya, ọ nwere ike ịkwalite mmetụta antihypertese siri ike ma na-eduga na hypotensiso. Ya mere, a machibidoro ojiji nke ọgwụ a machibidoro ndị na-eji α-proteptor. Nri na-egbu egbu (30% nke calorie abụba) enweghị mmetụta dị ukwuu na Chomokinokinetics nke otu ọgwụ nke otu ọgwụ nke ọgwụ a, na ihe oriri buru ibu (ihe karịrị 55% nke ọgwụ a kachasị elu bụ ihe dị ka 18%.

Ifuru Prashmashinetik
Ọ na-etinye ngwa ngwa mgbe nchịkwa ọnụ, ihe dị iche iche nke Mbadamba ụrọ bụ 15%, na nkezi oge ruo 1h (0.5-2). Ihe ngwọta nke 10mg ma ọ bụ 20mg, oge kacha elu bụ 0.9h na 0.7, nkezi platy classe itinye uche bụ 9μh / l na 21,1g / l, na oge nke ọgwụ nwere ike iru 1h. Ọkpụkpụ protein nke ọgwụ a dị ihe dị ka 95%. 1.5h mgbe otu ogwu nke 20 mg, ihe ọgwụ na semen ahụ bụ 0.500018% nke dose. Ọgwụ na-emejupụta ọgwụ na imeju site na cytochrome P450 (CP) 3A4, cyp 3A5 na cyp 2C9 Isozys. Isi metabolite bụ M1 kpụrụ site na oke ibu nke piperazimi nke ọgwụ a. M1 nwekwara mmetụta nke igbochi phosphadereSase 5 (ihe dị ka 7% nke arụmọrụ ya), na itinye ọbara ya bụ ihe dị ka 26% nke itinye uche nke nne na nna. , enwere ike ijikwu ya. Ọnụego ọgwụ ọjọọ nke ụdị metabolites na feces na mmamịrị dị ihe dịka 91% ruo 95% na 2% ruo 6%, n'otu n'otu. Ọnụego mkpochapụ nkịtị bụ 56 l kwa elekere, na ọkara nke nne na nna nyere ya onyinye na M1 dị ihe dị ka awa anọ ruo ise.