Caspofungin maka ọrịa antifungal
Nkọwa ngwaahịa
| Aha | Caspofungin |
| Nọmba CAS | 162808-62-0 |
| Usoro ihe omimi | C52H88N10O15 |
| Ibu arọ molekụla | 1093.31 |
| Nọmba EINECS | 1806241-263-5 |
| Ebe esi nri | 1408.1± 65.0 Celsius C (buru amụma) |
| Njupụta | 1.36±0.1 g/cm3 (buru amụma) |
| Ọnụọgụ acidity | (pKa) 9.86±0.26 (buru amụma) |
Ụdị okwu
CS-1171; Caspofungine; CASPOFUNGIN; CASPORFUNGIN; PneuMocandinB0,1-[(4R,5S) -5-[(2-aMinoethyl) aMino] -N2-(10,12-diMethyl). -1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R) -3-hydroxy-L-ornithine]-; CaspofunginMK-0991; Aids058650; Aids-058650
Njirimara kemịkalụ
Caspofungin bụ echinocandin izizi akwadoro maka ọgwụgwọ ọrịa fungal na-efe efe. Nnwale in vitro na in vivo gosipụtara na caspofungin nwere ezigbo ọrụ antibacterial megide nje nje ndị dị mkpa - Candida na Aspergillus. Caspofungin nwere ike ịgbaji mgbidi cell site na igbochi njikọ nke 1,3-β-glucan. Na ụlọ ọgwụ, caspofungin nwere mmetụta dị mma na ọgwụgwọ nke candidiasis dị iche iche na aspergillosis.
Mmetụta
(1,3) -D-glucan synthase bụ isi ihe dị mkpa nke njikọ mgbidi cell fungal, na caspofungin nwere ike ịkpata mmetụta antifungal site na enweghị asọmpi na-egbochi enzyme a. Mgbe nchịkwa eriri afọ gasịrị, ntinye ọgwụ plasma na-agbada ngwa ngwa n'ihi nkesa anụ ahụ, na-esote mwepụta nke ọgwụ ahụ nke nta nke nta na anụ ahụ. Metabolism nke caspofungin na-abawanye site n'ịbawanye dose ma na-ejikọta dose na oge iji kwụsie ike na ọtụtụ doses. Ya mere, iji nweta ọkwa ọgwụgwọ dị irè ma zere nchịkọta ọgwụ, a ga-edozi usoro ntinye mbụ na-esote usoro mmezi. Mgbe ị na-eji cytochrome p4503A4 inducers n'otu oge, dị ka rifampicin, carbamazepine, dexamethasone, phenytoin, wdg, a na-atụ aro ka ịbawanye dose nke caspofungin na-edozi.
Ngosipụta
Ngosipụta FDA kwadoro maka caspofungin gụnyere: 1. Ahụ ọkụ na neutropenia: akọwapụtara dị ka: ahụ ọkụ> 38 ° C nwere ọnụ ọgụgụ neutrophil zuru oke (ANC) ≤500/ml, ma ọ bụ na ANC ≤1000/ml na a na-ebu amụma na ọ nwere ike belata n'okpuru 500/ml. Dị ka ndụmọdụ nke Infectious Diseases Society of America (IDSA) si kwuo, ọ bụ ezie na a na-agwọ ndị ọrịa nwere ahụ ọkụ na-adịgide adịgide na neutropenia na ọgwụ nje dị iche iche, ndị ọrịa nwere nnukwu ihe ize ndụ ka na-atụ aro ka ha jiri ọgwụgwọ antifungal empiric, gụnyere caspofungin na ọgwụ ndị ọzọ na-egbu egbu. . 2. Candidiasis invasive: IDSA na-atụ aro echinocandins (dị ka caspofungin) dị ka ọgwụ nke nhọrọ maka candidemia. Enwere ike iji ya gwọọ ọnya afọ, peritonitis na ọrịa obi nke ọrịa Candida kpatara. 3. Esophageal candidiasis: Enwere ike iji Caspofungin na-agwọ ọrịa candidiasis nke esophageal na ndị ọrịa nwere nkwụsị ma ọ bụ anabataghị ọgwụgwọ ndị ọzọ. Ọtụtụ nchọpụta achọpụtala na mmetụta ọgwụgwọ nke caspofungin dị ka nke fluconazole. 4. Aspergillosis invasive: A kwadoro Caspofungin maka ọgwụgwọ nke aspergillosis na-emerụ ahụ na ndị ọrịa na-enweghị ndidi, nguzogide, na adịghị arụ ọrụ nke isi ọgwụ antifungal, voriconazole. Otú ọ dị, a naghị atụ aro echinocandin ka ọ bụrụ ọgwụgwọ nke mbụ.
