Caspofungin maka ọrịa antifung
Nkọwa nke ngwaahịa
| Aha | Castrofungin |
| Nọmba | 162808-62-0 |
| Molular | C52h88n10o15 |
| Molular ibu | 1093.31 |
| Nọmba einecs | 1806241-263-5 |
| Isi mmiri | 1408.1 ± 65.0 ° C (buru amụma) |
| Keuju | 1.36 ± 0.1 g / cm3 (buru amụma) |
| Acidity coefy | (Pka) 9.86 ± 0.26 (buru amụma) |
Myiri
CS-1171; Caspofungin; Castopocontin; pneudfucandinber,1 - [(AMINETYL) Amino ]- (10,12-Dimathyl -1-oextetradecysl) -4-hydroxy-l-orYahite] - (39); AIDS058650; AIDS-058650
Ngwongwo kemịkalụ
Caspofungin bụ Echinocanin kwadoro maka ọgwụgwọ nke ọrịa fungal. Na vitro na na Vivo na-egosi na Caspofigun nwere ezigbo nje mgbochi megide nje dị mkpa-sigrida na aspergiltus. Caspofundin nwere ike mebisie mgbidi nke cell site na igbochi njikọta 1,3-β-glucan. Caspofinin nwere mmetụta dị mma na ọgwụgwọ dị iche iche toodidis na aspergillosis.
Mputara
(1,3) -D-glucan Systan nke fungal synthesis, na Castrofunkin nwere ike na-arụ ọrụ antifung site na-egbochi enzyme a. Mgbe nchịkwa uche afọ, ịta ọgwụ plasma na-agbada ngwa ngwa n'ihi nkesa anụ ahụ, nke na-esochi ya nke ọma na-agbasa nke ọgwụ ahụ site na anụ ahụ. Metabolism nke Caspofigun mụbara na ịba ụba nke ịba ụba ma bụrụ ihe metụtara ya na oge iji kwụ ọtọ na steeti. Ya mere, iji nweta ọkwa ọgwụgwọ dị irè ma zere nchịkọta ọgwụ, a ga-enyerịrị dose dose site na mmezi mmezi. Mgbe ị na-eji kọmputa cytochrome P4503a4 n'otu oge, dịka rifampicin, cexmethine, dexamethine, phenytonin, wdg, a na-atụ aro ka ịbawanye mmezi mmezi nke Caspofundin.
Ngosiputa
Ihe ngosi FDA maka nnabata maka catrofunge gụnyere: Dabere na nkwanye nke ọrịa ọrịa na-efe efe (idsa), a na-atụ aro ndị ọrịa na-enweghị atụ na ndị na-eme ihe dị ize ndụ iji ọgwụ mgbochi Antiric na ọgwụ ndị ọzọ antifungun. . 2. A na-eme ka kandidis na-eme ka ihe nkiri: Idsa na-atụ aro Echinocandin (dịka Caspofungin) dị ka ọgwụ nke nhọrọ maka ekwentidemia. Enwere ike iji ya na-agwọta intra-afọ ime, peritonitis na ọrịa na-ebute ọrịa site na candida. 3. Enwere ike iji shophageals: Caspofungin nwere ike iji na-agwọ kansadiidisis na ndị ọrịa nwere ume ọhụrụ ma ọ bụ nweere ọgwụgwọ ndị ọzọ. Ọtụtụ nnyocha achọpụtala na mmetụta ọgwụgwọ ọrịa Caspofundin dị ka nke Fluconazole. 4. A na-echepụta aspergiltosis: A na-echepụta ihe dị mma maka ọgwụgwọ maka ọgwụgwọ nke a na-eme ka a na-eme ka a na-eleda anya na ọgwụ antifununal, Voriconazole. Agbanyeghị, a naghị atụ aro Echinocandin dị ka usoro ọgwụgwọ mbụ.
